Cytomegalovirus infection after liver transplantation in children

Mellon, A., Shepherd, R. W., Faoagali, J. L., Balderson, G., Ong, T. H., Patrick, M., Cleghorn, Geoffrey J., Lynch, S., & Strong, R. (1993) Cytomegalovirus infection after liver transplantation in children. Journal Of Gastroenterology And Hepatology, 8(6), pp. 540-544.

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Abstract

Post-liver transplant cytomegalovirus (CMV) infection (seroconversion or virus isolation) and CMV disease (infection plus clinical signs and symptoms) were studied in relation to pretransplant recipient and donor serology, age, nutritional status and the effect of paediatric versus adult (reduced size) grafts. Of 70 children receiving 79 transplants, 26 (37%) had evidence of CMV infection, and eight (11.5%) had evidence of CMV disease, four of whom died. The primary infection rate (where the recipients were CMV negative) was 71% with mortality of 7% with most receiving a CMV-positive graft. The active secondary infection rate (reactivation or reinfection, where the recipients were CMV positive) was 60% with mortality of 12.5%. No significant differences in infection on disease rates were found comparing malnourished versus well-nourished patients, or between those who received whole or reduced-size grafts. The high prevalence of CMV infections supports the view that clinical signs alone are inadequate to direct investigations for CMV. Both primary and active secondary CMV infection can result in serious morbidity and mortality in children receiving liver transplants. These data do not support the strategy of providing immunoprophylaxis to seronegative recipients only, at least in paediatric liver transplantation.

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9 citations in Web of Science®

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ID Code: 90255
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By :17
Export Date: 1 September 2015
CODEN: JGHEE
Correspondence Address: Shepherd, R.W.; Department of Child Health, Royal Children's Hospital, Herston, QLD 4029, Australia
Keywords: cytomegalovirus, liver, seroconversion, transplant, azathioprine, cyclosporin, ganciclovir, methylprednisolone, okt 3, prednisolone, article, child, controlled study, female, graft rejection, human, immunosuppressive treatment, intravenous drug administration, liver transplantation, major clinical study, male, oral drug administration, virus infection, Adolescent, Child, Preschool, Cytomegalovirus Infections, Infant, Nutritional Status, Postoperative Period
ISSN: 0815-9319
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Exercise & Nutrition Sciences
Deposited On: 17 Nov 2015 00:07
Last Modified: 17 Nov 2015 00:07

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