Nutritional rehabilitation in cystic fibrosis: A 5 year follow-up study

Dalzell, A. M., Shepherd, R. W., Dean, B., Cleghorn, Geoffrey J., Holt, T. L., & Francis, P. J. (1992) Nutritional rehabilitation in cystic fibrosis: A 5 year follow-up study. Journal of Pediatric Gastroenterology and Nutrition, 15(2), pp. 141-145.

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Previously, we reported catch-up weight gain, growth, and improved lung function in a group of malnourished cystic fibrosis (CF) children receiving aggressive nutritional supplementation for 1 year compared with a forced expiratory volume in 1 s (FEV1)-, height-, and sex-matched comparison group receiving standard therapy. To evaluate long-term effects, the clinical progress of both groups has been studied over a 5 year period. The supplemented group (n = 10) received supplements for a median of 1.35 years to achieve nutritional rehabilitation. Compared with the nonsupplemented group (n = 14), the previously supplemented group had lower mortality (2 vs. 4, N.S.) and significantly greater weight and height z scores at 4 and 5 years. The progression of pulmonary function abnormalities as measured by FEV, and forced vital capacity (FVC) slopes was greater at 3 years in the nonsupplemented group (FEV1, p < 0.05) but no significant differences in rates of deterioration of pulmonary function were seen after 5 years in the two groups of survivors. We conclude that intensive nutritional support for 1 year has both short-and long-term effects on nutrition and growth, still evident some years after the cessation of this therapeutic modality. Supplementation for periods of longer than 1 year may produce greater gains and possibly prolong the improvement in pulmonary function observed in the earlier study. © 1992 Raven Press, Ltd., New York.

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ID Code: 90258
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By :58
Export Date: 1 September 2015
Correspondence Address: Shepherd, R.W.; Department of Gastroenterology and Nutrition, Royal Children’s Hospital, Herston Road, Brisbane, QLD, 4029, Australia
Keywords: Cystic fibrosis, Lung function, Nutrition rehabilitation, article, catch up growth, child, clinical article, clinical feature, controlled study, follow up, forced expiratory volume, height, human, malnutrition, mortality, nutritional support, priority journal, weight gain, Adolescent, Adult, Body Height, Enteral Nutrition, Female, Follow-Up Studies, Male, Nutrition Disorders, Nutritional Status
ISSN: 0277-2116
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Exercise & Nutrition Sciences
Deposited On: 16 Nov 2015 23:36
Last Modified: 16 Nov 2015 23:36

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