Nutritional support in children with end-stage liver disease : a randomized crossover trial of a branched-chain amino acid supplement

Chin, S. E., Shepherd, R. W., Thomas, B. J., Cleghorn, Geoffrey J., Patrick, M. K., Wilcox, J. A., Ong, T. H., Lynch, S. V., & Strong, R. (1992) Nutritional support in children with end-stage liver disease : a randomized crossover trial of a branched-chain amino acid supplement. American Journal of Clinical Nutrition, 56(1), pp. 158-163.

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Malnutrition is common in children with end-stage liver disease (ESLD) awaiting orthotopic liver transplantation (OLT), and nutritional support is assuming an important role in preoperative management. To evaluate preoperative nutritional therapy, 19 children (median age 1.25 y) with ESLD awaiting OLT were prospectively studied. Two high-energy, isoenergetic and isonitrogenous nutritional formulations delivered nasogastrically were compared: a branched-chain amino acid (BCAA)-enriched semielemental formulation and a matched standard semielemental formulation. Twelve of 19 patients completed a randomized controlled study before OLT and 10 of 19 completed a full crossover study. Improvements in weight and height occurred during the BCAA supplements, with no statistical change on the standard formulation. Significant increases in total body potassium, midupper arm circumference, and subscapular skinfold thickness occurred during the BCAA supplements, whereas no significant changes occurred during the standard formulation period. Significantly fewer albumin infusions were required during the BCAA supplement. These findings suggest that BCAA-enriched formulas have advantages over standard semielemental formulas in improving nutritional status in children with ESLD. and are deserving of wider application and study.

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ID Code: 90261
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By :92 Export Date: 1 September 2015 CODEN: AJCNA Correspondence Address: Shepherd, R.W.; Department of Gastroenterology, Royal Children's Hospital, Herston, Brisbane, Qld. 4029, Australia
Keywords: Branched-chain amino acids, Enteral feeding, Liver diseases, Liver transplantation, Nutritional disorders, albumin, branched chain amino acid, anthropometry, article, body composition, child, childhood disease, clinical article, clinical feature, controlled study, crossover procedure, enteric feeding, female, human, infant, intragastric drug administration, intravenous drug administration, liver failure, liver function, male, malnutrition, nutritional status, nutritional support, priority journal, total body potassium, Albumins, Amino Acids, Amino Acids, Branched-Chain, Child, Preschool, Liver Function Tests, Potassium, Preoperative Care, Prospective Studies, Protein-Energy Malnutrition, Support, Non-U.S. Gov't
ISSN: 0002-9165
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Exercise & Nutrition Sciences
Deposited On: 17 Nov 2015 00:36
Last Modified: 17 Nov 2015 00:36

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