The nature of malnutrition in children with end-stage liver disease awaiting orthotopic liver transplantation

Chin, S. E., Shepherd, R. W., Thomas, B. J., Cleghorn, Geoffrey J., Patrick, M. K., Wilcox, J. A., Ong, T. H., Lynch, S. V., & Strong, R. (1992) The nature of malnutrition in children with end-stage liver disease awaiting orthotopic liver transplantation. American Journal of Clinical Nutrition, 56(1), pp. 164-168.

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To evaluate malnutrition in chronic liver disease, and its relationship to nutrient deficiencies and hepatic dysfunction. 27 children with end-stage liver disease were studied. Mean protein-energy intakes were 70% of recommended daily intakes. The patients were underweight and stunted with reduced mean triceps and subscapular skinfold thicknesses and midupper arm circumference. Mean total body potassium was only 63 ± 18% of that expected for age and sex. Deficiency of essential fatty acids (32%), and low concentrations of fat-soluble vitamins (A, 92%; E, 32%), iron (32%), zinc (42%), and selenium (13%) were common. Serum ammonia concentrations were raised in all patients, and increased methionine, tyrosine, and glutamic acid, and reduced glutamine concentrations were noted. There was no correlation between the degree of malnutrition and the degree of liver synthetic function, the degree of cholestasis, or the degree of liver injury. We suggest that potentially correctable factors in addition to liver failure (eg, inadequate absorbed intake) were important determinants of malnutrition in these patients.

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ID Code: 90262
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By :77
Export Date: 1 September 2015
Correspondence Address: Shepherd, R.W.; Department of Gastroenterology, Royal Children's Hospital, Herston, Brisbane, Qld. 4029, Australia
Keywords: Anthropometry, Body composition, Liver disease, Nutrition, amino acid blood level, ammonia blood level, article, child, childhood disease, cholestasis, clinical article, clinical feature, female, growth disorder, human, infant, laboratory test, liver dysfunction, liver failure, liver injury, male, malnutrition, nutritional deficiency, priority journal, retinol deficiency, total body potassium, vitamin deficiency, Amino Acids, Ammonia, Fatty Acids, Essential, Iron, Liver Diseases, Liver Transplantation, Potassium, Protein-Energy Malnutrition, Selenium, Support, Non-U.S. Gov't, Vitamins, Zinc
ISSN: 0002-9165
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Exercise & Nutrition Sciences
Deposited On: 17 Nov 2015 00:32
Last Modified: 17 Nov 2015 00:32

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