Early life stress, nicotinic acetylcholine receptors and alcohol use disorders

Holgate, Joan Y. & Bartlett, Selena E. (2015) Early life stress, nicotinic acetylcholine receptors and alcohol use disorders. Brain Sciences, 5(3), pp. 258-274.

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Stress is a major driving force in alcohol use disorders (AUDs). It influences how much one consumes, craving intensity and whether an abstinent individual will return to harmful alcohol consumption. We are most vulnerable to the effects of stress during early development, and exposure to multiple traumatic early life events dramatically increases the risk for AUDs. However, not everyone exposed to early life stress will develop an AUD. The mechanisms determining whether an individual’s brain adapts and becomes resilient to the effects of stress or succumbs and is unable to cope with stress remain elusive. Emerging evidence suggests that neuroplastic changes in the nucleus accumbens (NAc) following early life stress underlie the development of AUDs. This review discusses the impact of early life stress on NAc structure and function, how these changes affect cholinergic signaling within the mesolimbic reward pathway and the role nicotinic acetylcholine receptors (nAChRs) play in this process. Understanding the neural pathways and mechanism determining stress resilience or susceptibility will improve our ability to identify individuals susceptible to developing AUDs, formulate cognitive interventions to prevent AUDs in susceptible individuals and to elucidate and enhance potential therapeutic targets, such as the nAChRs, for those struggling to overcome an AUD.

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ID Code: 90268
Item Type: Journal Article
Refereed: Yes
Keywords: Early life stress, alcohol, nicotinic acetylcholine receptors, stress resilience, nucleus accumbens, cholinergic, mesolimbic, dopamine, GABA
DOI: 10.3390/brainsci5030258
ISSN: 2076-3425
Divisions: Current > Schools > School of Clinical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2015 by the authors
Copyright Statement: Licensee MDPI, Basel, Switzerland. This article is an open access article
distributed under the terms and conditions of the Creative Commons Attribution license
Deposited On: 16 Nov 2015 05:50
Last Modified: 17 Nov 2015 01:37

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