Flow pattern analysis in a highly stenotic patient-specific carotid bifurcation model using a turbulence model

Li, Z.Y., Tan, F.P.P., Soloperto, G., Wood, N. B., Xu, X. Y., & Gillard, J. H. (2015) Flow pattern analysis in a highly stenotic patient-specific carotid bifurcation model using a turbulence model. Computer Methods in Biomechanics and Biomedical Engineering, 18(10), pp. 1099-1107.

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The aim of this study is to investigate the blood flow pattern in carotid bifurcation with a high degree of luminal stenosis, combining in vivo magnetic resonance imaging (MRI) and computational fluid dynamics (CFD). A newly developed two-equation transitional model was employed to evaluate wall shear stress (WSS) distribution and pressure drop across the stenosis, which are closely related to plaque vulnerability. A patient with an 80% left carotid stenosis was imaged using high resolution MRI, from which a patient-specific geometry was reconstructed and flow boundary conditions were acquired for CFD simulation. A transitional model was implemented to investigate the flow velocity and WSS distribution in the patient-specific model. The peak time-averaged WSS value of approximately 73Pa was predicted by the transitional flow model, and the regions of high WSS occurred at the throat of the stenosis. High oscillatory shear index values up to 0.50 were present in a helical flow pattern from the outer wall of the internal carotid artery immediately after the throat. This study shows the potential suitability of a transitional turbulent flow model in capturing the flow phenomena in severely stenosed carotid arteries using patient-specific MRI data and provides the basis for further investigation of the links between haemodynamic variables and plaque vulnerability. It may be useful in the future for risk assessment of patients with carotid disease.

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2 citations in Scopus
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2 citations in Web of Science®

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ID Code: 90278
Item Type: Journal Article
Refereed: Yes
Keywords: MRI, shear stress, atherosclerosis, plaque vulnerability, luminal, stenosis, computational fluid-dynamics, moderate reynolds-numbers, pulsatile flow, shear-stress, blood-flow, atherosclerotic plaques, constricted tube, abdominal-aorta, stenoses, rupture
DOI: 10.1080/10255842.2013.873033
ISSN: 1476-8259
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2013 Taylor & Francis
Deposited On: 17 Nov 2015 04:17
Last Modified: 07 Dec 2015 22:47

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