How does calcification influence plaque vulnerability? Insights from fatigue analysis

Wu, B. J., Pei, X., & Li, Z. Y. (2014) How does calcification influence plaque vulnerability? Insights from fatigue analysis. The Scientific World Journal, 2014, pp. 1-8.

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Calcification is commonly believed to be associated with cardiovascular disease burden. But whether or not the calcifications have a negative effect on plaque vulnerability is still under debate.

Methods and Results

Fatigue rupture analysis and the fatigue life were used to evaluate the rupture risk. An idealized baseline model containing no calcification was first built. Based on the baseline model, we investigated the influence of calcification on rupture path and fatigue life by adding a circular calcification and changing its location within the fibrous cap area. Results show that 84.0% of calcified cases increase the fatigue life up to 11.4%. For rupture paths 10D far from the calcification, the life change is negligible. Calcifications close to lumen increase more fatigue life than those close to the lipid pool. Also, calcifications in the middle area of fibrous cap increase more fatigue life than those in the shoulder area.


Calcifications may play a positive role in the plaque stability. The influence of the calcification only exists in a local area. Calcifications close to lumen may be influenced more than those close to lipid pool. And calcifications in the middle area of fibrous cap are seemly influenced more than those in the shoulder area.

Impact and interest:

1 citations in Scopus
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2 citations in Web of Science®

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ID Code: 90281
Item Type: Journal Article
Refereed: Yes
Keywords: coronary-artery calcification, cardiovascular-disease, cellular, microcalcifications, cap thickness, fibrous caps, rupture, stability, hypothesis, calcium, impact
DOI: 10.1155/2014/417324
ISSN: 1537-744X
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2014 Baijian Wu et al.
Copyright Statement: This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Deposited On: 18 Nov 2015 03:45
Last Modified: 26 Nov 2015 06:30

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