Fatigue crack growth under pulsatile pressure and plaque rupture

Pei, X., Wu, B. J., Tang, T. Y., Gillard, J. H., & Li, Z. Y. (2014) Fatigue crack growth under pulsatile pressure and plaque rupture. JACC: Cardiovascular Imaging, 7(7), pp. 738-740.

View at publisher


Identification of vulnerable plaque pre-rupture is extremely important for patient risk stratification. The mechanism of plaque rupture is still not entirely clear, but it is thought to be a process involving multiple factors. From a biomechanical viewpoint, plaque rupture is usually seen as a structural failure when the plaque cannot resist the hemodynamic blood pressure and shear stress exerted on it. However, the cardiovascular system is naturally a cyclical hemodynamic environment, and myocardial infarction can be a symptomatically quiescent but potentially progressive process when plaque ruptures at stresses much lower than its strength. Therefore, fatigue accumulation is a possible mechanism for plaque rupture. In this study, a crack growth model was developed, and the previously-mentioned hypothesis was tested by conducting a comparative study between 18 symptomatic and 16 asymptomatic patients with carotid stenosis.

Impact and interest:

2 citations in Scopus
Search Google Scholar™
2 citations in Web of Science®

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 90282
Item Type: Journal Article
Refereed: Yes
Keywords: stress
DOI: 10.1016/j.jcmg.2014.01.019
ISSN: 1936-878X
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2014 American College of Cardiology Foundation
Deposited On: 18 Nov 2015 02:04
Last Modified: 25 Nov 2015 05:06

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page