Fatigue crack growth under pulsatile pressure and plaque rupture

Pei, X., Wu, B. J., Tang, T. Y., Gillard, J. H., & Li, Z. Y. (2014) Fatigue crack growth under pulsatile pressure and plaque rupture. JACC: Cardiovascular Imaging, 7(7), pp. 738-740.

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Abstract

Identification of vulnerable plaque pre-rupture is extremely important for patient risk stratification. The mechanism of plaque rupture is still not entirely clear, but it is thought to be a process involving multiple factors. From a biomechanical viewpoint, plaque rupture is usually seen as a structural failure when the plaque cannot resist the hemodynamic blood pressure and shear stress exerted on it. However, the cardiovascular system is naturally a cyclical hemodynamic environment, and myocardial infarction can be a symptomatically quiescent but potentially progressive process when plaque ruptures at stresses much lower than its strength. Therefore, fatigue accumulation is a possible mechanism for plaque rupture. In this study, a crack growth model was developed, and the previously-mentioned hypothesis was tested by conducting a comparative study between 18 symptomatic and 16 asymptomatic patients with carotid stenosis.

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2 citations in Web of Science®

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ID Code: 90282
Item Type: Journal Article
Refereed: Yes
Keywords: stress
DOI: 10.1016/j.jcmg.2014.01.019
ISSN: 1936-878X
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2014 American College of Cardiology Foundation
Deposited On: 18 Nov 2015 02:04
Last Modified: 25 Nov 2015 05:06

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