A hybrid cellular automata model of multicellular tumour spheroid growth in hypoxic microenvironment

Cai, Yan, Wu, Jie, Xu, Shixiong, & Li, Zhiyong (2013) A hybrid cellular automata model of multicellular tumour spheroid growth in hypoxic microenvironment. Journal of Applied Mathematics, 2013.

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Abstract

A three-dimensional hybrid cellular automata (CA) model is developed to study the dynamic process of multicellular tumour spheroid (MTS) growth by introducing hypoxia as an important microenvironment factor which influences cell migration and cell phenotype expression. The model enables us to examine the effects of different hypoxic environments on the growth history of the MTS and to study the dynamic interactions between MTS growth and chemical environments. The results include the spatial distribution of different phenotypes of tumour cells and associated oxygen concentration distributions under hypoxic conditions. The discussion of the model system responses to the varied hypoxic conditions reveals that the improvement of the resistance of tumour cells to a hypoxic environment may be important in the tumour normalization therapy.

Impact and interest:

3 citations in Scopus
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3 citations in Web of Science®

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3 since deposited on 16 Nov 2015
1 in the past twelve months

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ID Code: 90299
Item Type: Journal Article
Refereed: Yes
Additional Information: Article ID 519895
DOI: 10.1155/2013/519895
ISSN: 1687-0042
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2013 Yan Cai et al.
Copyright Statement: This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Deposited On: 16 Nov 2015 04:01
Last Modified: 09 Dec 2015 04:35

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