Curvedness study on atherosclerosis plaques and its implications to plaque stress

Gao, H., Long, Q., Graves, M., Li, Z. Y., & Gillard, J. H. (2010) Curvedness study on atherosclerosis plaques and its implications to plaque stress. In Lim, C. T. & Goh, J. C. H. (Eds.) 6th World Congress of Biomechanics (WCB 2010). August 1-6, 2010 Singapore: In Conjunction with 14th International Conference on Biomedical Engineering (ICBME) and 5th Asia Pacific Conference on Biomechanics (APBiomech), Springer Berlin Heidelberg, Suntec Convention Centre, Singapore, pp. 1507-1510.

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Abstract

Atherosclerosis plaque rupture has been considered to be a mechanical failure of the thin fibrous cap, resulted from extreme plaque stress. Plaque stress was affected by many factors from morphological features to biological abnormalities. In this study, geometrical factors (curvedness, fibrous cap thickness) were studied on assessing plaque vulnerability in comparison with stress analysis results obtained by fluid structure interaction from 20 human carotid atherosclerosis plaques. The results show that plaque surface curvedness could contribute to extreme stress level, especially in plaque shoulder region. General plaque stress distribution could be predicted by fibrous cap thickness and curvedness with multi-regression model. With more features included in the regression model, plaque stress could be easily calculated and used to assess plaque vulnerability.

Impact and interest:

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ID Code: 90325
Item Type: Conference Paper
Refereed: No
Keywords: Atherosclerosis plaque, curvedness, geometry features, plaque vulnerability, stress analysis
DOI: 10.1007/978-3-642-14515-5_384
ISBN: 9783642145155
ISSN: 1680-0737
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2010 International Federation for Medical and Biological Engineering
Deposited On: 30 Nov 2015 02:45
Last Modified: 04 Dec 2015 01:24

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