Stress analysis of carotid atheroma in a transient ischaemic attack patient using the MRI-based fluid-structure interaction method

Gao, H., Long, Q., Sadat, U., Graves, M., Gillard, J. H., & Li, Z. Y. (2009) Stress analysis of carotid atheroma in a transient ischaemic attack patient using the MRI-based fluid-structure interaction method. British Journal of Radiology, 82(SPEC.), S46-S54.

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Rupture of atherosclerotic plaque is a major cause of mortality. Plaque stress analysis, based on patient-specific multisequence in vivo MRI, can provide critical information for the understanding of plaque rupture and could eventually lead to plaque rupture prediction. However, the direct link between stress and plaque rupture is not fully understood. In the present study, the plaque from a patient who recently experienced a transient ischaemic attack (TIA) was studied using a fluid-structure interaction method to quantify stress distribution in the plaque region based on in vivo MR images. The results showed that wall shear stress is generally low in the artery with a slight increase at the plaque throat owing to minor luminal narrowing. The oscillatory shear index is much higher in the proximal part of the plaque. Both local wall stress concentrations and the relative stress variation distribution during a cardiac cycle indicate that the actual plaque rupture site is collocated with the highest rupture risk region in the studied patient.

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4 citations in Web of Science®

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ID Code: 90339
Item Type: Journal Article
Refereed: Yes
DOI: 10.1259/bjr/20307071
ISSN: 1748-880X
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2009 The British Institute of Radiology
Deposited On: 16 Nov 2015 05:39
Last Modified: 02 Dec 2015 05:32

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