Experimental measurement of the mechanical properties of carotid atherothrombotic plaque fibrous cap

Barrett, S. R. H., Sutcliffe, M. P. F., Howarth, S., Li, Z. Y., & Gillard, J. H. (2009) Experimental measurement of the mechanical properties of carotid atherothrombotic plaque fibrous cap. Journal of Biomechanics, 42(11), pp. 1650-1655.

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Eleven carotid atherothrombotic plaque samples were harvested from patients. Three samples that were highly calcified were discarded, while eight yielded results. The elastic properties of the material were estimated by fitting the measured indentation response to finite element simulations. The methodology was refined and its accuracy quantified using a synthetic rubber. The neo-Hookean form of the material model gave a good fit to the measured response of the tissue. The inferred shear modulus μ was found to be in the range 7-100 kPa, with a median value of 11 kPa. A review of published materials data showed a wide range of material properties for human atherothrombotic tissue. The effects of anisotropy and time dependency in these published results were highlighted. The present measurements were comparable to the static radial compression tests of Lee et al, 1991 [Structure-dependent dynamic behaviour of fibrous caps from human atherosclerotic plaques. Circulation 83, 1764-1770].

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ID Code: 90344
Item Type: Journal Article
Refereed: No
Keywords: Atherothrombosis, Carotid artery, Indentation, Modulus, Plaque
DOI: 10.1016/j.jbiomech.2009.04.025
ISSN: 0021-9290
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2009 Elsevier Ltd
Deposited On: 18 Nov 2015 02:08
Last Modified: 18 Nov 2015 02:08

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