In vivo non-invasive high resolution MR-based method for the determination of the elastic modulus of arterial vessels

Taviani, V., Sutcliffe, M. P. F., Wong, P., Li, Z. Y., Young, V., Graves, M. J., & Gillard, J. H. (2008) In vivo non-invasive high resolution MR-based method for the determination of the elastic modulus of arterial vessels. In Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society : "Personalized Healthcare through Technology" ; August, 20-24, 2008, Vancouver Convention & Exhibition Centre, Vancouver, British Columbia, Ca, IEEE, Vancouver, Canada, pp. 5569-5572.

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The mechanical properties of arterial walls have long been recognized to play an essential role in the development and progression of cardiovascular disease (CVD). Early detection of variations in the elastic modulus of arteries would help in monitoring patients at high cardiovascular risk stratifying them according to risk. An in vivo, non-invasive, high resolution MR-phase-contrast based method for the estimation of the time-dependent elastic modulus of healthy arteries was developed, validated in vitro by means of a thin walled silicon rubber tube integrated into an existing MR-compatible flow simulator and used on healthy volunteers. A comparison of the elastic modulus of the silicon tube measured from the MRI-based technique with direct measurements confirmed the method's capability. The repeatability of the method was assessed. Viscoelastic and inertial effects characterizing the dynamic response of arteries in vivo emerged from the comparison of the pressure waveform and the area variation curve over a period. For all the volunteers who took part in the study the elastic modulus was found to be in the range 50-250 kPa, to increase during the rising part of the cycle, and to decrease with decreasing pressure during the downstroke of systole and subsequent diastole.

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ID Code: 90347
Item Type: Conference Paper
Refereed: No
DOI: 10.1109/IEMBS.2008.4650476
ISBN: 9781424418152
ISSN: 1557-170X
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2008 IEEE
Deposited On: 30 Nov 2015 05:17
Last Modified: 04 Dec 2015 03:16

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