Combined PET-FDG and USPIO-enhanced MR imaging in patients with symptomatic moderate carotid artery stenosis

Tang, T. Y., Moustafa, R. R., Howarth, S. P., Walsh, S. R., Boyle, J. R., Li, Z. Y., Baron, J. C., Gillard, J. H., & Warburton, E. A. (2008) Combined PET-FDG and USPIO-enhanced MR imaging in patients with symptomatic moderate carotid artery stenosis. European Journal of Vascular and Endovascular Surgery, 36(1), pp. 53-55.

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PET-FDG and USPIO-enhanced MRI are increasingly being used in depicting carotid atheroma inflammation - a risk factor for the high risk plaque. Their combined use has not been previously reported.


Two patients presenting with stroke and identified with 50% carotid stenosis on duplex ultrasonography, underwent PET FDG and USPIO-enhanced MR imaging. Results were concordant and complementary suggesting that both techniques reflect similar metabolic processes.


The selection of patients for carotid revascularisation has largely been based on the severity of luminal stenosis alone. The two imaging modalities, which identify inflammatory activity, may be potential surrogate risk markers in the selection of patients eligible for carotid surgery, if plaque inflammation can be correlated with risk of developing clinical symptoms.

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15 citations in Scopus
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13 citations in Web of Science®

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ID Code: 90348
Item Type: Journal Article
Refereed: Yes
Keywords: Imaging, MRI, Positron emission tomography, Stroke, Symptomatic Carotid stenosis, USPIO
DOI: 10.1016/j.ejvs.2008.02.006
ISSN: 1532-2165
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2008 European Society for Vascular Surgery
Deposited On: 16 Nov 2015 02:48
Last Modified: 02 Dec 2015 05:10

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