Correlation of carotid atheromatous plaque inflammation using USPIO-enhanced MR imaging with degree of luminal Stenosis

Tang, T. Y., Howarth, S. P. S., Miller, S. R., Graves, M. J., U-King-Im, J. M., Li, Z. Y., Walsh, S. R., Patterson, A. J., Kirkpatrick, P. J., Warburton, E. A., Varty, K., Gaunt, M. E., & Gillard, J. H. (2008) Correlation of carotid atheromatous plaque inflammation using USPIO-enhanced MR imaging with degree of luminal Stenosis. Stroke, 39(7), pp. 2144-2147.

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Inflammation is a recognized risk factor for the vulnerable atherosclerotic plaque. The study explores the relationship between the degree of Magnetic Resonance (MR)"defined inflammation using Ultra Small Super-Paramagnetic Iron Oxide (USPIO) particles and the severity of luminal stenosis in asymptomatic carotid plaques.


Seventy-one patients with an asymptomatic carotid stenosis of ĝ‰¥40% underwent multi-sequence USPIO-enhanced MR imaging. Stenosis severity was measured according to the NASCET and ECST methods.


No demonstrable relationship between inflammation as measured by USPIO-enhanced signal change and the degree of luminal stenosis was found.


Inflammation and stenosis are likely to be independent risk factors, although this needs to be further validated.

Impact and interest:

40 citations in Scopus
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31 citations in Web of Science®

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ID Code: 90349
Item Type: Journal Article
Refereed: Yes
Keywords: Asymptomatic carotid stenosis, Atherosclerosis, Inflammation, MRI, Plaque vulnerability, USPIO
DOI: 10.1161/STROKEAHA.107.504753
ISSN: 1524-4628
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2008 American Heart Association, Inc.
Deposited On: 16 Nov 2015 23:33
Last Modified: 19 Oct 2016 04:52

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