Impact of calcification and intraluminal thrombus on the computed wall stresses of abdominal aortic aneurysm

Li, Z. Y., U-King-Im, J., Tang, T. Y., Soh, E., See, T. C., & Gillard, J. H. (2008) Impact of calcification and intraluminal thrombus on the computed wall stresses of abdominal aortic aneurysm. Journal of Vascular Surgery, 47(5), pp. 928-935.

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Abstract

Background:

Increased biomechanical stresses within the abdominal aortic aneurysm (AAA) wall contribute to its rupture. Calcification and intraluminal thrombus can be commonly found in AAAs, but the relationship between calcification/intraluminal thrombus and AAA wall stress is not completely described.

Methods:

Patient-specific three-dimensional AAA geometries were reconstructed from computed tomographic images of 20 patients. Structural analysis was performed to calculate the wall stresses of the 20 AAA models and their altered models when calcification or intraluminal thrombus was not considered. A nonlinear large-strain finite element method was used to compute the wall stress distribution. The relationships between wall stresses and volumes of calcification and intraluminal thrombus were sought.

Results:

Maximum stress was not correlated with the percentage of calcification, and was negatively correlated with the percentage of intraluminal thrombus (r = -0.56; P = .011). Exclusion of calcification from analysis led to a significant decrease in maximum stress by a median of 14% (range, 2%-27%; P < .01). When intraluminal thrombus was eliminated, maximum stress increased significantly by a median of 24% (range, 5%-43%; P < .01).

Conclusion:

The presence of calcification increases AAA peak wall stress, suggesting that calcification decrease the biomechanical stability of AAA. In contrast, intraluminal thrombus reduces the maximum stress in AAA. Calcification and intraluminal thrombus should both be considered in the evaluation of wall stress for risk assessment of AAA rupture.

Impact and interest:

87 citations in Scopus
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81 citations in Web of Science®

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ID Code: 90352
Item Type: Journal Article
Refereed: Yes
DOI: 10.1016/j.jvs.2008.01.006
ISSN: 1097-6809
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2008 The Society for Vascular Surgery
Deposited On: 18 Nov 2015 02:18
Last Modified: 18 Nov 2015 02:18

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