Measurement of stenotic carotid arterial compliance with MRI

Li, Z. Y., Howarth, S., Graves, M., & Gillard, J. H. (2008) Measurement of stenotic carotid arterial compliance with MRI. In Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society : "personalized healthcare through technology" : August 20-24, 2008, Vancouver Convention & Exhibition Centre, Vancouver, British Columbia, Can, IEEE, Vancouver, Canada, pp. 1403-1406.

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Arterial compliance has been shown to correlate well with overall cardiovascular outcome and it may also be a potential risk factor for the development of atheromatous disease. This study assesses the utility of 2-D phase contrast Magnetic Resonance (MR) imaging with intra-sequence blood pressure measurement to determine carotid compliance and distensibility. 20 patients underwent 2-D phase contrast MR imaging and also ultrasound-based wall tracking measurements. Values for carotid compliance and distensibility were derived from the two different modalities and compared. Linear regression analysis was utilised to determine the extent of correlation between MR and ultrasound derived parameters. In those variables that could be directly compared, an agreement analysis was undertaken. MR measures of compliance showed a good correlation with measures based on ultrasound wall-tracking (r=0.61, 95% CI 0.34 to 0.81 p=0.0003). Vessels that had undergone carotid endarterectomy previously were significantly less compliant than either diseased or normal contralateral vessels (p=0.04). Agreement studies showed a relatively poor intra-class correlation coefficient (ICC) between diameter-based measures of compliance through either MR or ultrasound (ICC=0.14). MRI based assessment of local carotid compliance appears to be both robust and technically feasible in most subjects. Measures of compliance correlate well with ultrasound-based values and correlate best when cross-sectional area change is used rather than derived diameter changes. If validated by further larger studies, 2-D phase contrast imaging with intra-sequence blood pressure monitoring and off-line radial artery tonometry may provide a useful tool in further assessment of patients with carotid atheroma.

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ID Code: 90355
Item Type: Conference Paper
Refereed: No
DOI: 10.1109/IEMBS.2008.4649428
ISBN: 9781424418152
ISSN: 1557-170X
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2008 IEEE
Deposited On: 30 Nov 2015 07:01
Last Modified: 04 Dec 2015 03:32

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