Correlation of macrophage location and plaque stress distribution using USPIO-enhanced MRI in a patient with symptomatic severe carotid stenosis: A new insight into risk stratification

Howarth, S., Li, Z. Y., Trivedi, R. A., U-King-Im, J. M., Graves, M. J., Kirkpatrick, P. J., & Gillard, J. H. (2007) Correlation of macrophage location and plaque stress distribution using USPIO-enhanced MRI in a patient with symptomatic severe carotid stenosis: A new insight into risk stratification. British Journal of Neurosurgery, 21(4), pp. 396-398.

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Abstract

High resolution, USPIO-enhanced MR imaging can be used to identify inflamed atherosclerotic plaque. We report a case of a 79-year-old man with a symptomatic carotid stenosis of 82%. The plaque was retrieved for histology and finite element analysis (FEA) based on the preoperative MR imaging was used to predict maximal Von Mises stress on the plaque. Macrophage location correlated with maximal predicted stresses on the plaque. This supports the hypothesis that macrophages thin the fibrous cap at points of highest stress, leading to an increased risk of plaque rupture and subsequent stroke.

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17 citations in Scopus
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13 citations in Web of Science®

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ID Code: 90365
Item Type: Journal Article
Refereed: Yes
Keywords: Atheroma, Carotid, FEA, Macrophage, MRI, Stress
DOI: 10.1080/02688690701400775
ISSN: 1360-046X
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2007 The Neurosurgical Foundation.
Deposited On: 16 Nov 2015 23:42
Last Modified: 16 Nov 2015 23:42

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