Association of NOS1AP variants and depression phenotypes in schizophrenia

Cheah, Sern-Yih, Lawford, Bruce R., Young, Ross McD., Morris, C. Phillip, & Voisey, Joanne (2015) Association of NOS1AP variants and depression phenotypes in schizophrenia. Journal of Affective Disorders, 188, pp. 263-269.

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The nitric oxide synthase 1 adaptor protein gene (NOS1AP) has previously been recognised as a schizophrenia susceptibility gene due to its role in glutamate neurotransmission. The gene is believed to inhibit nitric oxide (NO) production activated by the N-methyl-d-aspartate (NMDA) receptor and reduced NO levels have been observed in schizophrenia patients. However, association studies investigating NOS1AP and schizophrenia have produced inconsistent results, most likely because schizophrenia is a clinically heterogeneous disorder. This study aims to investigate the association between NOS1AP variants and defined depression phenotypes of schizophrenia.


Nine NOS1AP SNPs, rs1415259, rs1415263, rs1858232, rs386231, rs4531275, rs4656355, rs4657178, rs6683968 and rs6704393 were genotyped in 235 schizophrenia subjects screened for various phenotypes of depression.


One NOS1AP SNP (rs1858232) was associated with the broad diagnosis of schizophrenia and eight SNPs were associated with depression related phenotypes within schizophrenia. The rs1415259 SNP showed strong association with sleep dysregulation phenotypes of depression.


Results suggest that NOS1AP variants are associated with various forms of depression in schizophrenia and are more prevalent in males.


Schizophrenia is a clinically heterogeneous disease that can vary greatly between different ethnic and geographic populations so our observations should be viewed with caution until they are independently replicated, particularly in larger patient cohorts.

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ID Code: 90400
Item Type: Journal Article
Refereed: Yes
Keywords: Schizophrenia; NOS1AP; Polymorphism; SNP; Psychiatric phenotypes; Depression
DOI: 10.1016/j.jad.2015.08.069
ISSN: 0165-0327
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Crown Copyright 2015
Copyright Statement: This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Deposited On: 17 Nov 2015 05:10
Last Modified: 22 Nov 2015 06:00

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