Biophysical response of living cells to boron nitride nanoparticles: Uptake mechanism and bio-mechanical characterization

Rasel, Md. Alim Iftekhar, Li, Tong, Nguyen, Trung Dung, Singh, Sanjleena, Zhou, Yinghong, Xiao, Yin, & Gu, YuanTong (2015) Biophysical response of living cells to boron nitride nanoparticles: Uptake mechanism and bio-mechanical characterization. Journal of Nanoparticle Research, 17(11), Article: 441.

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Abstract

Boron nitride nanomaterials have attracted significant interest due to their superior chemical and physical properties. Despite these novel properties, investigation on the interaction between boron nitride nanoparticle (BN NP) and living systems has been limited. In this study, BN NP (100–250 nm) is assessed as a promising biomaterial for medical applications. The toxicity of BN NP is evaluated by assessing the cells behaviours both biologically (MTT assay, ROS detection etc.) and physically (atomic force microscopy). The uptake mechanism of BN NP is studied by analysing the alternations in cellular morphology based on cell imaging techniques. The results demonstrate in vitro cytocompatibility of BN NP with immense potential for use as an effective nanoparticle for various bio-medical applications.

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ID Code: 90511
Item Type: Journal Article
Refereed: Yes
Keywords: Boron nitride, Nanoparticles, Biomechanics, Cytotoxicity, Atomic Force Microscopy
DOI: 10.1007/s11051-015-3248-2
ISSN: 1572-896X
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomechanical Engineering (090302)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > MECHANICAL ENGINEERING (091300)
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute for Future Environments
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Funding:
Facilities: Science and Engineering Centre
Copyright Owner: Copyright 2015 Springer Science+Business Media Dordrecht
Copyright Statement: The final publication is available at Springer via http://dx.doi.org/10.1007/s11051-015-3248-2
Deposited On: 20 Nov 2015 04:46
Last Modified: 07 Dec 2016 22:56

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