Kallikrein-related peptidases in prostate cancer: From molecular function to clinical application

Fuhrman-Luck, Ruth A., Loessner, Daniela, & Clements, Judith A. (2014) Kallikrein-related peptidases in prostate cancer: From molecular function to clinical application. Electronic Journal of the International Federation of Clinical Chemistry, 25(3), pp. 49-61.

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Prostate cancer is a leading contributor to male cancer-related deaths worldwide. Kallikrein-related peptidases (KLKs) are serine proteases that exhibit deregulated expression in prostate cancer, with KLK3, or prostate specific antigen (PSA), being the widely-employed clinical biomarker for prostate cancer. Other KLKs, such as KLK2, show promise as prostate cancer biomarkers and, additionally, their altered expression has been utilised for the design of KLK-targeted therapies. There is also a large body of in vitro and in vivo evidence supporting their role in cancer-related processes. Here, we review the literature on studies to date investigating the potential of other KLKs, in addition to PSA, as biomarkers and in therapeutic options, as well as their current known functional roles in cancer progression. Increased knowledge of these KLK-mediated functions, including degradation of the extracellular matrix, local invasion, cancer cell proliferation, interactions with fibroblasts, angiogenesis, migration, bone metastasis and tumour growth in vivo, may help define new roles as prognostic biomarkers and novel therapeutic targets for this cancer.

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ID Code: 90537
Item Type: Journal Article
Refereed: Yes
Keywords: prostate cancer, kallikrein-related peptidase, biomarker
ISSN: 1650-3414
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 22 Nov 2015 23:59
Last Modified: 24 Nov 2015 05:06

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