Survival, growth and quality of life in children after orthotopic liver transplantation: A 5 year experience

Chin, S. E., Shepherd, R. W., Cleghorn, G. J., Patrick, M. K., Javorsky, G., Frangoulis, E., Balderson, G., Koido, Y., Matsunami, H., Lynbch, S. V., Strong, R., & Ong, T. H. (1991) Survival, growth and quality of life in children after orthotopic liver transplantation: A 5 year experience. Journal of Paediatrics and Child Health, 27(6), pp. 380-385.

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The aims of this study were to investigate outcome and to evaluate areas of potential ongoing concern after orthotopic liver transplantation (OLT) in children. Actuarial survival in relation to age and degree of undernutrition at the time of OLT was evaluated in 53 children (age 0.58-14.2 years) undergoing OLT for endstage liver disease. Follow-up studies of growth and quality of life were undertaken in those with a minimum follow-up period of 12 months (n = 26). The overall 3 year actuarial survival was 70%. Survival rates did not differ between age groups (actuarial 2 year survival for ages <1, 1-5 and >5 years were 70, 70 and 69% respectively) but did differ according to nutritional status at OLT (actuarial 2 year survival for children with Z scores for weight <-1 was 57%, >-1 was 95%; P = 0.004). Significant catch-up weight gain was observed by 18 months post-transplant, while height improved less rapidly. Quality of life (assessed by Vineland Adaptive Behaviour Scales incorporating socialization, daily living skills, communication and motor skills) was good (mean composite score 91 ± 19). All school-aged children except one were attending normal school. Two children had mild to moderate intellectual handicap related to post-operative intracerebral complications. Satisfactory long-term survival can be achieved after OLT in children regardless of age but the importance of pre-operative nutrition is emphasized. Survivors have an excellent chance of a good quality of life and of satisfactory catch-up weight gain and growth.

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82 citations in Scopus
68 citations in Web of Science®
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ID Code: 90544
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By :73
Export Date: 1 September 2015
Keywords: academic achievement, adolescent, article, child, female, follow up, growth, human, infant, liver transplantation, major clinical study, male, nutritional status, priority journal, quality of life, survival, weight gain, Activities of Daily Living, Actuarial Analysis, Body Height, Body Weight, Child, Preschool, Follow-Up Studies, Liver Diseases, Support, Non-U.S. Gov't, Survival Rate, Treatment Outcome
DOI: 10.1111/j.1440-1754.1991.tb00424.x
ISSN: 1034-4810
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Wiley-Blackwell Publishing Ltd
Deposited On: 19 Nov 2015 04:25
Last Modified: 19 Nov 2015 04:25

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