Protein turnover in malnourished patients with cystic fibrosis: Effects of elemental and nonelemental nutritional supplements

Pelekanos, J. T., Holt, T. L., Ward, L. C., Cleghorn, G. J., & Shepherd, R. W. (1990) Protein turnover in malnourished patients with cystic fibrosis: Effects of elemental and nonelemental nutritional supplements. Journal of Pediatric Gastroenterology and Nutrition, 10(3), pp. 339-343.

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To evaluate the relative efficacy of nonele-mental versus semielemental enteral supplements for nutritional rehabilitation of cystic fibrosis (CF) patients, whole-body protein turnover using the [15N]glycine method was studied in nine malnourished CF patients during enteral feedings, in a block design study compar-ing a semielemental formula (Criticare), a higher protein density but nonelemental formula (Traumacal) (T), and a nonelemental formula that had been modified to become isocaloric and isonitrogenous to the semielemental formula (modified Traumacal, MT). No significant differences in rates of protein synthesis or catabolism were observed comparing the three formulas. However the higher protein density nonelemental formula resulted in higher net protein deposition compared to the other two formulas (T + 0.42 g kg-110 h-1versus 0.33 g kg-110 h-1for Criticare and-0.59 g kg-110 h-1for MT), although this was significant (p < 0.05) for the MT versus T comparison only. This study lends support to the use of less expensive nonelemental formulas for the nutritional management of malnourished patients with CF. © 1990 Raven Press Ltd, New York.

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ID Code: 90546
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By :3
Export Date: 1 September 2015
Correspondence Address: Holt, T.L.; Department of Paediatric Gastroenterology and Nutrition, Royal Children’s Hospital, Brisbane, QLD, Australia
Keywords: Cystic fibrosis, Nutritional therapy, Protein turnover, adolescent, article, clinical article, human, malnutrition, nutritional support, preschool child, priority journal, protein metabolism, school child, Child, Child Nutrition, Child Nutrition Disorders, Child, Preschool, Comparative Study, Energy Intake, Food, Formulated, Glycine, Nutritional Status, Proteins, Whole-Body Counting
ISSN: 0277-2116
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright Lippincott Williams & Wilkins
Deposited On: 19 Nov 2015 04:07
Last Modified: 19 Nov 2015 04:07

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