Cyclosporin-responsive enteropathy and protracted diarrhea

Coulthard, M., Searle, J., Patrick, M., Ravenscroft, P., Cleghorn, G. J., & Shepherd, R. (1990) Cyclosporin-responsive enteropathy and protracted diarrhea. Journal of Pediatric Gastroenterology and Nutrition, 10(2), pp. 257-261.

View at publisher (open access)


We describe a child bom to unrelated parents who developed severe protracted secretory type diarrhea associated with subtotal villus atrophy and intestinal inflammation at the age of 19 months. No infectious, metabolic, or anatomical basis for this condition was identified and the child required total parenteral nutrition for a period of 18 months despite trials of special enteral formulas, steroids, and anti-inflammatory agents. This refractory “enteropathy” responded dramatically to the introduction of cyclosporin, with cessation of the secretory diarrhea, recovery from the enteropathy, and cessation of parenteral nutrition. The symptoms relapsed when cyclosporin was briefly discontinued and improved following reintroduction of this drug. This experience suggests a role for immune factors in the pathogenesis of the enteropathy in this case and that a trial of cyclosporin is worthy of consideration in similar cases. © 1990 Raven Press, Ltd., New York.

Impact and interest:

11 citations in Scopus
6 citations in Web of Science®
Search Google Scholar™

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 90547
Item Type: Journal Article
Refereed: No
Additional Information: Cited By :10
Export Date: 1 September 2015
Correspondence Address: Shepherd, R.; Department of Gastroenterology and Nutrition, Royal Children’s Hospital, Brisbane, QLD, 4029, Australia
Keywords: Autoimmune enteropathy, Bioavailability, Cyclosporin, Intractable diarrhea, Refractory enteropathy, article, case report, chronic diarrhea, drug efficacy, enteropathy, female, histology, human, pathogenesis, preschool child, priority journal, Cyclosporins, Diarrhea, Infantile, Enteritis, Infant, Newborn
ISSN: 0277-2116
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright Lippincott Williams & Wilkins
Deposited On: 19 Nov 2015 03:57
Last Modified: 19 Nov 2015 03:57

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page