Cyclosporin-responsive enteropathy and protracted diarrhea
Coulthard, M., Searle, J., Patrick, M., Ravenscroft, P., Cleghorn, G. J., & Shepherd, R. (1990) Cyclosporin-responsive enteropathy and protracted diarrhea. Journal of Pediatric Gastroenterology and Nutrition, 10(2), pp. 257-261.
We describe a child bom to unrelated parents who developed severe protracted secretory type diarrhea associated with subtotal villus atrophy and intestinal inflammation at the age of 19 months. No infectious, metabolic, or anatomical basis for this condition was identified and the child required total parenteral nutrition for a period of 18 months despite trials of special enteral formulas, steroids, and anti-inflammatory agents. This refractory “enteropathy” responded dramatically to the introduction of cyclosporin, with cessation of the secretory diarrhea, recovery from the enteropathy, and cessation of parenteral nutrition. The symptoms relapsed when cyclosporin was briefly discontinued and improved following reintroduction of this drug. This experience suggests a role for immune factors in the pathogenesis of the enteropathy in this case and that a trial of cyclosporin is worthy of consideration in similar cases. © 1990 Raven Press, Ltd., New York.
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|Item Type:||Journal Article|
|Additional Information:||Cited By :10
Export Date: 1 September 2015
Correspondence Address: Shepherd, R.; Department of Gastroenterology and Nutrition, Royal Children’s Hospital, Brisbane, QLD, 4029, Australia
|Keywords:||Autoimmune enteropathy, Bioavailability, Cyclosporin, Intractable diarrhea, Refractory enteropathy, article, case report, chronic diarrhea, drug efficacy, enteropathy, female, histology, human, pathogenesis, preschool child, priority journal, Cyclosporins, Diarrhea, Infantile, Enteritis, Infant, Newborn|
|Divisions:||Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright Lippincott Williams & Wilkins|
|Deposited On:||19 Nov 2015 03:57|
|Last Modified:||19 Nov 2015 03:57|
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