Comparison of two oral rehydration solutions in children with gastroenteritis in Australia

Cleghorn, G.J., Shepherd, R.W., Patrick, M.K., & Chin, S.E. (1990) Comparison of two oral rehydration solutions in children with gastroenteritis in Australia. Clinical Therapeutics, 12(Sup), pp. 81-85.

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An open-label inpatient study is in progress to compare the efficacy and safety of two oral rehydration solutions in children and infants with acute diarrhea and mild to moderate dehydration. One solution (ORS-60) contains 60 mmol/L of sodium and 1.8% glucose, with a total osmolatity of 240 mosm/kg; the other (ORS-26) contains 26 mmol/L of sodium, 2.7% glucose, and 3.6% sucrose, with a total osmolality of 340 mosm/kg. An outcome analysis of 28 children with gastroenteritis indicated that ORS-60 (n = 13) reduced stool volume during the first eight hours after admission to a significantly greater (P < 0.05) extent than did ORS-26 (n = 15). Diarrhea had ceased by 24 hours in 64% of ORS-60 patients but in only 31% of ORS-26 patients, and the patients' clinical conidition was improved at eight hours in 84% of ORS-60 patients versus 60% of ORS-26 patients. Differences between treatments in degree of dehydration at each follow-up point, total duration of diarrhea, and duration of hospital stay were not detected. No adverse drug reactions occurred. Four patients received intravenous rehydration therapy, but none was considered a treatment failure. We conclude that the lower osmolar solution, ORS-60, conferred earlier recovey and reduced continuing fluid losses in the management of gastroenteritis.

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ID Code: 90548
Item Type: Journal Article
Refereed: Yes
Keywords: oral rehydration solution, acute diarrhea, australia, child, clinical article, conference paper, controlled study, dehydration, drug efficacy, drug safety, female, gastroenteritis, human, male, osmolality, priority journal, rehydration, Child, Preschool, Fluid Therapy, Humans, Infant, Infant, Newborn, Osmolar Concentration, Solutions
ISSN: 0149-2918
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Deposited On: 23 Nov 2015 22:24
Last Modified: 23 Nov 2015 22:24

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