Exploring methods of preparing functional cartilage-bone xenografts for joint repair

Heidarkhan Tehrani, Ashkan (2015) Exploring methods of preparing functional cartilage-bone xenografts for joint repair. PhD thesis, Queensland University of Technology.


This thesis explores the feasibility of donor-receiver concept for joint replacement where cartilage-bone tissues can be taken from either human or other mammals and prepared scientifically for repairing focal joint defects in knees, hips and shoulders. The manufactured construct is immunologically inert and is capable of acting as a scaffold for engineering new cartilage-bone laminates when placed in the joint. Innovative manufacturing procedures and assessment techniques were developed for appraising this tissue-based scaffold. This research has demonstrated that tissue replacement technology can be applied in situations where blood vessels are absent such as in articular cartilage.

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ID Code: 90556
Item Type: QUT Thesis (PhD)
Supervisor: Oloyede, Kunle, Xiao, Yin, & Singh, Sanjleena
Keywords: Joint repair, Cartilage-on-bone laminate, Decellularization, Focal defect, ECM-scaffold, Microchannel, Collagen network, Laser ablation, Sterilization, Microengineering
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Institution: Queensland University of Technology
Deposited On: 11 Jan 2016 04:57
Last Modified: 31 Jul 2016 14:00

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