Sequential allocation in clinical trials

Wang, Y-G. (1991) Sequential allocation in clinical trials. Communications in Statistics: Theory and Methods, 20(3), pp. 791-805.

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Suppose two treatments with binary responses are available for patients with some disease and that each patient will receive one of the two treatments. In this paper we consider the interests of patients both within and outside a trial using a Bayesian bandit approach and conclude that equal allocation is not appropriate for either group of patients. It is suggested that Gittins indices should be used (using an approach called dynamic discounting by choosing the discount rate based on the number of future patients in the trial) if the disease is rare, and the least failures rule if the disease is common. Some analytical and simulation results are provided.

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4 citations in Scopus
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5 citations in Web of Science®

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ID Code: 90634
Item Type: Journal Article
Refereed: Yes
Additional Information: ISI Document Delivery No.: FR391
Times Cited: 5
Cited Reference Count: 20
Wang, yg
Marcel dekker inc
New york
Keywords: adaptive allocation, clinical trial, gittins index, play-the-winner rule, multi-armed bandits
DOI: 10.1080/03610929108830531
ISSN: 0361-0926
Divisions: Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright Taylor and Francis
Deposited On: 24 Nov 2015 06:07
Last Modified: 24 Nov 2015 06:07

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