Quantifying progressive anterior overgrowth in the thoracic vertebrae of adolescent idiopathic scoliosis patients

Newell, Nicolas, Grant, Caroline A., Keenan, Bethany E., Izatt, Maree T., Pearcy, Mark J., & Adam, Clayton J. (2016) Quantifying progressive anterior overgrowth in the thoracic vertebrae of adolescent idiopathic scoliosis patients. Spine, 41(7), E382-E387.

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Abstract

Study design

  • Anterior and posterior vertebral body heights were measured from sequential MRI scans of adolescent idiopathic scoliosis (AIS) patients and healthy controls.

Objective

  • To measure changes in vertebral body height over time during scoliosis progression to assess how vertebral body height discrepancies change during growth.

Summary of background data

  • Relative anterior overgrowth has been proposed as a potential driver for AIS initiation and progression. This theory proposes that the anterior column grows faster, and the posterior column slower, in AIS patients when compared to healthy controls. There is disagreement in the literature as to whether the anterior vertebral body heights are proportionally greater than posterior vertebral body heights in AIS patients when compared to healthy controls. To some extent, these discrepancies may be attributed to methodological differences.

Methods

  • MRI scans of the major curve of 21 AIS patients (mean age 12.5 ± 1.4 years, mean Cobb 32.2 ± 12.8º) and between T4 and T12 of 21 healthy adolescents (mean age 12.1 ± 0.5 years) were captured for this study. Of the 21 AIS patients, 14 had a second scan on average 10.8 ± 4.7 months after the first. Anterior and posterior vertebral body heights were measured from the true sagittal plane of each vertebra such that anterior overgrowth could be quantified.

Results

  • The difference between anterior and posterior vertebral body height in healthy, non-scoliotic children was significantly greater than in AIS patients with mild to moderate scoliosis. However there was no significant relationship between the overall anterior-posterior vertebral body height difference in AIS and either severity of the curve or its progression over time.

Conclusions

  • Whilst AIS patients have a proportionally longer anterior column than non-scoliotic controls, the degree of anterior overgrowth was not related to the rate of progression or the severity of the scoliotic curve.

Impact and interest:

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ID Code: 90712
Item Type: Journal Article
Refereed: Yes
Keywords: adolescent idiopathic scoliosis, healthy spine control, thoracic scoliosis, anterior vertebral body, anterior overgrowth, magnetic resonance imaging, sequential MRI, scoliosis progression, vertebral body height
DOI: 10.1097/BRS.0000000000001265
ISSN: 0362-2436
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomechanical Engineering (090302)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CLINICAL SCIENCES (110300) > Nuclear Medicine (110313)
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2015 Wolters Kluwer Health, Inc
Deposited On: 24 Nov 2015 23:32
Last Modified: 30 May 2016 05:03

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