Development of a novel experimental model to investigate the influence of mechanics on bone healing

Tufekci, Pelin Melisa (2015) Development of a novel experimental model to investigate the influence of mechanics on bone healing. PhD thesis, Queensland University of Technology.

Abstract

This dissertation proposed a novel experimental model combining a defect configuration with an active instrumented fixation device to investigate the influence of mechanics on bone healing. The proposed defect configuration aimed to minimise physiological loading within an experimental fracture gap and the instrumented fixator was used for the application of controlled displacements and in vivo stiffness monitoring of the healing process. This thesis has provided a novel approach to advance current knowledge and understanding of mechanobiology, which has been limited in previous experimental models.

Impact and interest:

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50 since deposited on 11 Jan 2016
50 in the past twelve months

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ID Code: 90730
Item Type: QUT Thesis (PhD)
Supervisor: Epari, Devakar, Steck, Roland, & Glatt, Vaida
Keywords: Fracture healing, Mechanobiology, Ovine model, Mechanical stimulation, External stimulation, Interfragmentary movement, Osteotomy, Animal model
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Institution: Queensland University of Technology
Deposited On: 11 Jan 2016 05:39
Last Modified: 12 Jan 2016 01:51

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