Total body potassium in cystic fibrosis

Shepherd, R. W., Holt, T. L., Greer, R., Cleghorn, Geoffrey J., & Thomas, B. J. (1989) Total body potassium in cystic fibrosis. Journal of Pediatric Gastroenterology and Nutrition, 9(2), pp. 200-205.

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Abstract

To further evaluate the nature of malnutrition, define at-risk groups, and confirm the efficacy of nutritional supplementation on body composition in cystic fibrosis (CF), we have conducted longitudinal and cross-sectional studies of total body potassium (TBK) in 161 unselected CF subjects aged 1 month to 17 years. TBK was determined by measurement of40K in a whole body counter, reflecting body cell mass (BCM), the vital work-performing and growing cellular component of the body. Compared with normal TBK data for age and sex from pooled measurements of 1,629 healthy children aged 1 week to 17 years, CF infants (n = 12) diagnosed by newborn screening were depleted in TBK at diagnosis and showed catch-up with therapy by 1 year; CF children aged 2-17 years (n = 140) showed a tendency for inadequate accretion of TBK (and thus BCM) with increasing age, although the normal correlation between TBK and weight and height was maintained in the majority suggesting a pattern of nutritional stunting of growth; and malnourished CF children (n = 9) showed significant catchup in TBK with long-term nutritional rehabilitation (85-98% of TBK predicted for weight and height). These studies suggest that potentially serious, but possibly correctable deficits, in the growth of the body cell mass as measured by TBK occur commonly in CF. These deficits may be established very early in life and if not corrected lead to progressive nutritional growth retardation with increasing age. © 1989 Raven Press, Ltd., New York.

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ID Code: 90742
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By :31
Export Date: 1 September 2015
Correspondence Address: Shepherd, R.W.; Department of Gastroenterology and Nutrition, Royal Children’s Hospital, Brisbane, QLD, 4029, Australia
Keywords: Body composition, Cystic fibrosis, Malnutrition, Total body potassium, radioisotope, adolescent, child, controlled study, growth retardation, human, infant, major clinical study, nutrition, priority journal, whole body counting, Child, Preschool, Infant, Newborn, Longitudinal Studies, Nutrition Disorders, Nutritional Status, Potassium, Risk Factors, Support, Non-U.S. Gov't
ISSN: 0277-2116
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Exercise & Nutrition Sciences
Deposited On: 25 Nov 2015 01:38
Last Modified: 25 Nov 2015 01:38

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