Lavage treatment of distal intestinal obstruction syndrome in children with cystic fibrosis

Koletzko, S., Stringer, D. A., Cleghorn, Geoffrey J., & Durie, P. R. (1989) Lavage treatment of distal intestinal obstruction syndrome in children with cystic fibrosis. Pediatrics (English edition), 83(5), pp. 727-733.

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The efficacy, adverse reactions, and long-term effects of intestinal lavage treatment with a balanced electrolyte solution (Golytely) was evaluated in patients with cystic fibrosis and distal intestinal obstruction syndrome. Twenty-two patients with cystic fibrosis (mean age 21.8 years, range 14 to 34 years, 15 boys or men) who sough medical attention because of abdominal pain and a mass in the right iliac fossa received Golytely, 5.6 ± 1.9 L (mean ± 1 SD), either orally (n = 14) or via nasogastric tube (n = 8) during 5.6 ± 2.4 hours. No serious side effects occurred. Serum electrolyte values remained within normal limits. Body weight did not change significantly. Minor adverse reactions included bloating (n = 12), nausea (n = 8), vomiting (n = 1), and chills (n = 3). All but one patient reported impressive relief of symptoms and remained pain free for an average of 3 months (range 1 to 19 months). Symptoms of abdominal pain and radiologic signs of fecal impaction assessed before and after lavage both decreased significantly (P < .0001). During follow-up (mean 15.2 months, range 4 to 26 months), 11 patients required a total of 38 (range one to nine) additional doses of Golytely. Seven patients drank the solution at home (21 treatments); only two patients chose a nasogastric tube. In ten patients with symptoms of recurrent distal intestinal obstruction syndrome prior to institution of therapy, duration of hospitalization was significantly reduced by this treatment (5.1 ± 7.6 v 2.3 ± 6.3 hospital days per annum, P < .02). It is concluded that intestinal lavage is a well-accepted, safe, and effective therapy for distal intestinal obstruction syndrome in patients with cystic fibrosis.

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ID Code: 90748
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By :41
Export Date: 1 September 2015
Keywords: golytely, abdominal mass, abdominal pain, adolescent, adult, clinical article, cystic fibrosis, drug efficacy, drug safety, electrolyte blood level, feces, female, follow up, human, intestine lavage, intestine obstruction, male, nasogastric tube, oral drug administration, priority journal, Electrolytes, Intestinal Obstruction, Irrigation
ISSN: 0031-4005
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Exercise & Nutrition Sciences
Deposited On: 25 Nov 2015 02:47
Last Modified: 25 Nov 2015 02:47

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