Short-term nutritional supplementation during management of pulmonary exacerbations in cystic fibosis: A controlled study, including effects of protein turnover
Shepherd, R. W., Holt, T. L., Cleghorn, Geoffrey J., Ward, L. C., Isles, A., & Francis, P. (1988) Short-term nutritional supplementation during management of pulmonary exacerbations in cystic fibosis: A controlled study, including effects of protein turnover. American Journal of Clinical Nutrition, 48(2), pp. 235-239.
Effects of nutritional supplements on minimizing weight loss and abnormalities of protein turnover during pulmonary exacerbations in cystic fibrosis (CF) were studied by controlled trial. Patients received pulmonary therapy and either standard diet (n = 10) or adjunctive enteral supplements (n = 12). Initial protein turnover, measured by [15N]glycine kinetics, showed alterations of protein synthesis (P Syn) and catabolism (P Cat), which correlated with the degree of underweight, and negligible net protein deposition (P Dep). With treatment both groups had significant increases in mean body weight and forced expiratory volume in 1 s, expressed as percent predicted value for height (FEV1) by 3 wk, but a significant correlation between initial underweight and subsequent weight gain was observed only in supplemented patients. Mean P Syn and P Dep increased significantly (p < 0.001) only in the supplemented group. Pulmonary exacerbations in CF have important adverse effects on body-protein metabolism, similar to changes in protein-energy malnutrition and infection. These effects are reversed by short-term nutritional support. Strategic nutritional intervention should thus be considered in management, especially in malnourished patients.
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|Item Type:||Journal Article|
|Additional Information:||Cited By :24 Export Date: 1 September 2015 CODEN: AJCNA|
|Keywords:||adolescent, clinical article, cystic fibrosis, female, human, lung infection, male, nutrition, priority journal, protein metabolism, school child, Body Weight, Child, Clinical Trials, Enteral Nutrition, Forced Expiratory Volume, Lung, Mathematics, Pneumonia, Proteins, Respiration, Support, Non-U.S. Gov't|
|Divisions:||Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Exercise & Nutrition Sciences
|Deposited On:||25 Nov 2015 02:14|
|Last Modified:||25 Nov 2015 02:14|
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