The biochemistry of blister fluid from pediatric burn injuries: proteomics and metabolomics aspects

Tuo, Zang, Broszczak, Daniel, Broadbent, James A., Cuttle, Leila, Lu, Haitao, & Parker, Tony J. (2016) The biochemistry of blister fluid from pediatric burn injuries: proteomics and metabolomics aspects. Expert review of proteomics, 13(1), pp. 35-53.

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Burn injury is a prevalent and traumatic event for pediatric patients. At present, the diagnosis of burn injury severity is subjective and lacks a clinically relevant quantitative measure. This is due in part to a lack of knowledge surrounding the biochemistry of burn injuries and that of blister fluid. A more complete understanding of the blister fluid biochemistry may open new avenues for diagnostic and prognostic development. Burn insult induces a highly complex network of signaling processes and numerous changes within various biochemical systems, which can ultimately be examined using proteome and metabolome measurements. This review reports on the current understanding of burn wound biochemistry and outlines a technical approach for ‘omics’ profiling of blister fluid from burn wounds of differing severity.

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ID Code: 90812
Item Type: Journal Article
Refereed: Yes
Keywords: pediatric burns, mass spectrometry, proteomics, metabolomics, nuclear magnetic resonance, blister fluid
DOI: 10.1586/14789450.2016.1122528
ISSN: 1744-8387
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > MEDICAL BIOCHEMISTRY AND METABOLOMICS (110100)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Taylor & Frances 2015
Deposited On: 26 Nov 2015 23:14
Last Modified: 30 May 2016 04:53

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