Age-related alterations in immunoreactive pancreatic lipase and cationic trypsinogen in young children with cystic fibrosis

Cleghorn, Geoffrey, Benjamin, Lynne, Corey, Mary, Forstner, Gordon, Dati, Francesco, & Durie, Peter (1985) Age-related alterations in immunoreactive pancreatic lipase and cationic trypsinogen in young children with cystic fibrosis. Journal of Pediatrics, 107(3), pp. 377-381.

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Serum immunoreactive pancreatic lipase and cationic trypsinogen are elevated in young infants with cystic fibrosis (CF) and may be useful neonatal screening tests for CF. We compared lipase measured by a recently developed ELISA immunoassay with trypsinogen measured by radioimmunoassay in 70 children (ages 0.1 to 9.9 years) with CF who had various degrees of pancreatic dysfunction and in 79 similarly aged children without CF (controls). In the control children, lipase activity increased with advancing age, whereas trypsinogen showed no age-related trend. Lipase and trypsinogen were significantly elevated in the infants with CF who were younger than 1 year, irrespective of pancreatic function (trypsinogen, P<0.001; lipase, P<0.05). Sensitivities in detecting CF were 76% and 90% for lipase and trypsinogen, respectively. After the first year of life, lipase and trypsinogen values declined toward normal, the rate of decline of lipase being greater than that of trypsinogen; 67% of lipase values were within or below the normal range by 3 years, whereas 67% of trypsinogen values continued to be elevated. We conclude that trypsinogen is an excellent screening test for CF in young infants regardless of pancreatic function, and that the addition of a serum pancreatic lipase determination does not improve the accuracy of trypsinogen as a screening test for cystic fibrosis.

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ID Code: 90925
Item Type: Journal Article
Refereed: Yes
Keywords: triacylglycerol lipase, trypsinogen, accuracy, age, child, clinical article, congenital disorder, controlled study, cystic fibrosis, diagnosis, digestive system, human, infant, newborn screening, pancreas, priority journal, radioimmunoassay, respiratory system, screening, Age Factors, Child, Preschool, Fetal Blood, Humans, Infant, Newborn, Lipase
DOI: 10.1016/S0022-3476(85)80510-2
ISSN: 0022-3476
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Exercise & Nutrition Sciences
Deposited On: 02 Dec 2015 04:54
Last Modified: 02 Dec 2015 04:54

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