Structure of the K6 capsular polysaccharide from Acinetobacter baumannii isolate RBH4

Kenyon, Johanna J., Marzaioli, Alberto M., Hall, Ruth M., & De Castro, Cristina (2015) Structure of the K6 capsular polysaccharide from Acinetobacter baumannii isolate RBH4. Carbohydrate Research, 409, pp. 30-35.

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Abstract

The structure of the capsular polysaccharide (CPS) from an Acinetobacter baumannii global clone 2 (GC2) clinical isolate RBH4 that carries the KL6 gene cluster was elucidated by means of chemical and spectroscopical methods. The repeating unit of K6 CPS is linear and contains N-acetyl-d-galactosamine (d-GalpNAc), two d-galactose (d-Galp) residues and 5,7-di-N-acetylpseudaminic acid (Pse5Ac7Ac). The synthesis of these sugars could be attributed to genes in the KL6 capsule biosynthesis gene cluster, and the formation of the linkages between the sugars were assigned to glycosyltransferases or the Wzy polymerase encoded in KL6.

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ID Code: 90941
Item Type: Journal Article
Refereed: Yes
Keywords: Capsular polysaccharide, K locus, KL6 gene cluster, NMR spectroscopy, Pseudaminic acid, Pseudaminic acid
DOI: 10.1016/j.carres.2015.03.016
ISSN: 1873-426X
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > MICROBIOLOGY (060500)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > MICROBIOLOGY (060500) > Bacteriology (060501)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > MICROBIOLOGY (060500) > Microbial Genetics (060503)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Funding:
Copyright Owner: Copyright 2015 Elsevier
Deposited On: 02 Dec 2015 01:28
Last Modified: 02 Dec 2015 22:13

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