A liquid biopsy for head and neck cancers

Schmidt, Henri, Kulasinghe, Arutha, Perry, Chris, Nelson, Colleen, & Punyadeera, Chamindie (2016) A liquid biopsy for head and neck cancers. Expert Review of Molecular Diagnostics.

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Head and neck cancer patients often present with advanced metastatic disease resulting in a poor 5-year survival. Therefore, there is a need for non-invasive diagnostic tools that could complement conventional imaging to inform clinicians of patient outcomes and treatment responses. A liquid biopsy addresses this unmet clinical need; a simple peripheral blood draw could provide information about the disseminated disease in terms of circulating tumor cells and circulating tumor DNA. Moreover, detectable tumor DNA in the saliva of head and neck cancer patients could signify the early signs of the disease and present an opportunity for clinical intervention. This review provides an overview of the current literature with regard to the feasibility of such a test in the head and neck cancer field and highlights the need for such a test.

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1 citations in Web of Science®

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ID Code: 91057
Item Type: Journal Article
Refereed: Yes
Keywords: Circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), Head and Neck Cancer (HNC), Head and neck squamous cell carcinoma (HNSCC), Human papillomavirus (HPV)
DOI: 10.1586/14737159.2016.1127758
ISSN: 1744-8352
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Cell Biology (111201)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Diagnosis (111202)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2015 Taylor & Francis
Copyright Statement: The Version of Record of this manuscript has been published and is available in Expert Review of Molecular Diagnostics, 18 January 2016, http://www.tandfonline.com/10.1586/14737159.2016.1127758
Deposited On: 07 Dec 2015 23:46
Last Modified: 05 Feb 2016 06:50

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