Solubility of ibuprofen in aqueous ethanol at low ethanol contents
Afrose, Afrina, White, Edward T., Howes, Tony, George, Graeme, Rashid, Abdur, & Islam, Nazrul (2015) Solubility of ibuprofen in aqueous ethanol at low ethanol contents. In Asia Pacific Confederation of Chemical Engineering Congress 2015 (APCChE 2015) incorporating CHEMECA 2015, Engineers Australia, Melbourne, Vic.
The solubility of ibuprofen was measured in water (W) - ethanol (E) mixtures from 0 to 50% w/w ethanol at 10, 25 and 40 °C by the dissolution method using UV spectrophotometry to determine the ibuprofen concentrations. The UV calibration for ibuprofen in different water - ethanol mixtures showed Beer - Lambert linearity, however the slopes differed, which indicated the structure of the drug is influenced by the solvent system i.e. the water - ethanol ratio. The ibuprofen solubility in water (zero ethanol) is low (~ 50 ppm) but increases near exponentially with increasing ethanol content. At 40 °C, there is phase separation between 34% and 63% w/w E/(E+W). The solubility data will be used to select precipitation crystallizer conditions to directly produce free flowing ibuprofen particles (<5 m) for developing a dry powder inhaler (DPI) formulation for lung delivery.
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|Item Type:||Conference Paper|
|Keywords:||Ibuprofen, solubility, aqueous ethanol, dissolution, UV spectrophotometry|
|Divisions:||Current > Schools > School of Clinical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
|Deposited On:||17 Dec 2015 23:22|
|Last Modified:||25 Feb 2016 21:40|
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