Preparation and in vitro release of drug-loaded microparticles for oral delivery using wholegrain sorghum kafirin protein

Lau, Esther T.L., Johnson, Stuart K., Stanley, Roger A., Mikkelsen, Deirdre, Fang, Zhongxiang, Halley, Peter J., & Steadman, Kathryn J. (2015) Preparation and in vitro release of drug-loaded microparticles for oral delivery using wholegrain sorghum kafirin protein. International Journal of Polymer Science, 2015, 343647-8 pages.

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Abstract

Kafirin microparticles have been proposed as an oral nutraceutical and drug delivery system. This study investigates microparticles formed with kafirin extracted from white and raw versus cooked red sorghum grains as an oral delivery system. Targeted delivery to the colon would be beneficial for medication such as prednisolone, which is used in the management of inflammatory bowel disease. Therefore, prednisolone was loaded into microparticles of kafirin from the different sources using phase separation. Differences were observed in the protein content, in vitro protein digestibility, and protein electrophoretic profile of the various sources of sorghum grains, kafirin extracts, and kafirin microparticles. For all of the formulations, the majority of the loaded prednisolone was not released in in vitro conditions simulating the upper gastrointestinal tract, indicating that most of the encapsulated drug could reach the target area of the lower gastrointestinal tract. This suggests that these kafirin microparticles may have potential as a colon-targeted nutraceutical and drug delivery system.

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ID Code: 91359
Item Type: Journal Article
Refereed: Yes
DOI: 10.1155/2015/343647
ISSN: 1687-9422
Divisions: Current > Schools > School of Clinical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Copyright Owner: Copyright 2015 Esther T. L. Lau et al.
Copyright Statement: This is an open access article distributed under the Creative Commons Attribution License,
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Deposited On: 18 Dec 2015 00:23
Last Modified: 04 Jan 2016 02:09

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