Urinary tract infection of mice to model human disease: Practicalities, implications and limitations

Carey, Alison J., Tan, Chee K., Ipe, Deepak S., Sullivan, Matthew J., Cripps, Allan W., Schembri, Mark A., & Ulett, Glen C. (2016) Urinary tract infection of mice to model human disease: Practicalities, implications and limitations. Critical Reviews in Microbiology, 42(5), pp. 780-799.

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Abstract

Urinary tract infections (UTIs) are among the most common bacterial infections in humans. Murine models of human UTI are vital experimental tools that have helped to elucidate UTI pathogenesis and advance knowledge of potential treatment and infection prevention strategies. Fundamentally, several variables are inherent in different murine models, and understanding the limitations of these variables provides an opportunity to understand how models may be best applied to research aimed at mimicking human disease. In this review, we discuss variables inherent in murine UTI model studies and how these affect model usage, data analysis and data interpretation. We examine recent studies that have elucidated UTI host–pathogen interactions from the perspective of gene expression, and review new studies of biofilm and UTI preventative approaches. We also consider potential standards for variables inherent in murine UTI models and discuss how these might expand the utility of models for mimicking human disease and uncovering new aspects of pathogenesis.

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ID Code: 91392
Item Type: Journal Article
Refereed: Yes
Keywords: Animal models, Escherichia coli, innate immunity, urinary tract infection, bacterial pathogenesis
DOI: 10.3109/1040841X.2015.1028885
ISSN: 1549-7828
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > MICROBIOLOGY (060500) > Bacteriology (060501)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > IMMUNOLOGY (110700) > Innate Immunity (110707)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2015 Taylor & Francis Group
Deposited On: 17 Dec 2015 22:55
Last Modified: 01 Dec 2016 14:01

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