Quality of life changes during conformal radiation therapy for prostate carcinoma

Janda, Monika, gerstner, Natascha, Obermair, Andreas, fuerst, annerose, wachter, Guertel, dieckman, Karin, & potter, richard (2000) Quality of life changes during conformal radiation therapy for prostate carcinoma. Cancer, 89(6), pp. 1322-1328.

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The objective of this study was to describe prospectively quality of life (QOL) before and after radiotherapy for patients with prostate carcinoma.


Forty-three patients with T1-T3 prostate carcinoma who underwent conformal external beam radiation therapy were randomized either to the complete European Organization for Research and Treatment of Cancer (EORTC) QOL questionnaire (EORTC QLQ-C30) or the Medical Outcomes Study Group Short Form Health Survey (SF-36) at baseline, at 3 weeks and 6 weeks after initial treatment, and at 6 weeks and 5 months after the completion of radiotherapy. The measures were self-reported patient QOL, and values are given as the mean +/- standard error of the mean. Changes in QOL are described from baseline to the end of treatment in both questionnaire groups.


Emotional role functioning, as measured with the SF-36 questionnaire, significantly improved from 68.2 +/- 9.9 at baseline to 93.3 +/- 5.2 at the end of therapy (P = 0.02). The EORTC QLQ-C30 questionnaire revealed consistent values of emotional functioning during treatment (72.7 +/- 5.9 at baseline) but showed a significant improvement 6 weeks after therapy (89.0 +/- 4.4; P = 0.01). Role functioning deteriorated from 80.1 +/- 6.5 at baseline to 62.5 +/- 8.8 at the end of radiotherapy (P = 0.02). Symptoms of fatigue were shown to increase significantly from 26.9 +/- 6.0 at baseline to 37.7 +/- 7.6 at the end of therapy (P = 0.02). No significant changes in the other dimensions were observed in either questionnaire.


After radiotherapy for prostate carcinoma, patients experience a temporary deterioration of fatigue and role functioning, as measured with the EORTC QLQ-C-30. Despite physical deterioration, the authors observed an improvement in emotional functioning scores with both questionnaires. This may have been due to psychological adaptation and coping.

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ID Code: 91454
Item Type: Journal Article
Refereed: Yes
DOI: 10.1002/1097-0142(20000915)89:6<1322::AID-CNCR18>3.0.CO;2-D
ISSN: 1097-0142
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Public Health & Social Work
Copyright Owner: Copyright 2000 American Cancer Society
Deposited On: 23 Dec 2015 03:17
Last Modified: 23 Dec 2015 03:17

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