Hypoxic corneal changes following eight hours of scleral contact lens wear

Vincent, Stephen J., Alonso-Caneiro, David, Collins, Michael J., Beanland, Alison, Lam, Linda, Lim, Ching Chong, Loke, Alyssa, & Nguyen, Nhi (2016) Hypoxic corneal changes following eight hours of scleral contact lens wear. Optometry and Vision Science, 93(3), pp. 293-299.

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Abstract

  • Purpose

To examine the change in corneal thickness and posterior curvature following 8 hours of miniscleral contact lens wear.

  • Methods

Scheimpflug imaging (Pentacam HR, Oculus) was captured before, and immediately following, 8 hours of miniscleral contact lens wear for 15 young (mean age 22 ± 3 years), healthy participants with normal corneae. Natural diurnal variations were considered by measuring baseline corneal changes obtained on a separate control day without contact lens wear.

  • Results

Over the central 6 mm of the cornea, a small, but highly statistically significant amount of edema was observed following 8 hours of miniscleral lens wear, after accounting for normal diurnal fluctuations (mean ± standard deviation percentage swelling 1.70 ± 0.98%, p < 0.0001). Posterior corneal topography remained stable following lens wear (-0.01 ± 0.07 mm steepening over the central 6 mm, p = 0.60). The magnitude of posterior corneal topographical changes following lens wear did not correlate with the extent of lens-related corneal edema (r = -0.16, p = 0.57). Similarly, the initial central corneal vault (maximum post-lens tear layer depth) was not associated with corneal swelling following lens removal (r = 0.27, p = 0.33).

  • Conclusions

While a small amount of corneal swelling was induced following 8 hours of miniscleral lens wear (on average <2%), modern high Dk miniscleral contact lenses that vault the cornea do not induce clinically significant corneal edema or hypoxic related posterior corneal curvature changes during short-term wear. Longer-term studies of compromised eyes (e.g. corneal ectasia) are still required to inform the optimum lens and fitting characteristics for safe scleral lens wear to minimize corneal hypoxia.

Impact and interest:

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ID Code: 91465
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Miniscleral contact lens, Corneal oedema, Posterior corneal curvature, Hypoxia
DOI: 10.1097/OPX.0000000000000803
ISSN: 1538-9235
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Optometry & Vision Science
Copyright Owner: Copyright 2015 Lippincott Williams & Wilkins
Copyright Statement: This is a non-final version of an article published in final form in Optometry and Vision Science, 93(3), p.293-299.
Deposited On: 22 Dec 2015 23:33
Last Modified: 10 Jun 2016 07:47

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