Design and characterisation of scaffolds for osteochondral regeneration

Bartnikowski, Michal (2015) Design and characterisation of scaffolds for osteochondral regeneration. PhD by Publication, Queensland University of Technology.

Abstract

Treatment of joint diseases such as osteoarthritis is difficult and requires extensive developments for adequate solutions to emerge. Continued innovation in projects explored in this thesis may be beneficial to understanding the requirements of the joint environment. This may then lead to constructs that perform desirably from both mechanical and biological standpoints, resulting in complete, tissue-engineered osteochondral solutions.

This thesis investigated specific scaffold designs for bone and osteochondral tissue engineering, as well as the formation of complex criteria on which cartilage hydrogel scaffolds may be assessed.

The combination of hydrogels and ceramics were found to maintain chondrogenesis, while the concentration of photoinitiators in photocrosslinkable hydrogel systems may be optimised to maximise mechanical properties and cell viability. Finally, viscoelasticity of hydrogel blends was assessed using oscillatory motion, demonstrating the property is tailorable.

Impact and interest:

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17 since deposited on 12 May 2016
17 in the past twelve months

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ID Code: 91548
Item Type: QUT Thesis (PhD by Publication)
Supervisor: Klein, Travis & Woodruff, Mia
Keywords: cartilage, hydrogel, melt extrusion, additive manufacture, osteoarthritis, osteochondral, photocrosslinking, photopolymerisation, regenerative medicine, tissue engineering
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Institution: Queensland University of Technology
Deposited On: 12 May 2016 01:52
Last Modified: 29 Jun 2016 02:54

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