CYP19A1 fine-mapping and Mendelian randomization: Estradiol is causal for endometrial cancer

Thompson, D. J., O'Mara, T. A., Glubb, D. M., Painter, J. N., Cheng, T., Folkerd, E., Doody, D., Dennis, J., Webb, P. M., Gorman, M., Martin, L., Hodgson, S., Michailidou, K., Tyrer, J. P., Maranian, M. J., Hall, P., Czene, K., Darabi, H., Li, J., Fasching, P. A., Hein, A., Beckmann, M. W., Ekici, A. B., Dork, T., Hillemanns, P., Durst, M., Runnebaum, I., Zhao, H., Depreeuw, J., Schrauwen, S., Amant, F., Goode, E. L., Fridley, B. L., Dowdy, S. C., Winham, S. J., Salvesen, H. B., Trovik, J., Njolstad, T. S., Werner, H. M., Ashton, K., Proietto, T., Otton, G., Carvajal-Carmona, L., Tham, E., Liu, T., Mints, M., Scott, R. J., McEvoy, M., Attia, J., Holliday, E. G., Montgomery, G. W., Martin, N. G., Nyholt, D.R., Henders, A. K., Hopper, J. L., Traficante, N., Ruebner, M., Swerdlow, A. J., Burwinkel, B., Brenner, H., Meindl, A., Brauch, H., Lindblom, A., Lambrechts, D., Chang-Claude, J., Couch, F., Giles, G., Kristensen, V. N., Cox, A., Bolla, M. K., Wang, Q., Bojesen, S. E., Shah, M., Luben, R., Khaw, K.-T., Pharoah, P. D., Dunning, A. M., Tomlinson, I., Dowsett, M., Easton, D. F., & Spurdle, A. B. (2016) CYP19A1 fine-mapping and Mendelian randomization: Estradiol is causal for endometrial cancer. Endocrine-Related Cancer, 23(2), pp. 77-91.

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Candidate gene studies have reported CYP19A1 variants to be associated with endometrial cancer and with estradiol (E2) concentrations. We analyzed 2937 single nucleotide polymorphisms (SNPs) in 6608 endometrial cancer cases and 37 925 controls and report the first genome wide-significant association between endometrial cancer and a CYP19A1 SNP (rs727479 in intron 2, P=4.8x10(-11)). SNP rs727479 was also among those most strongly associated with circulating E2 concentrations in 2767 post-menopausal controls (P=7.4x10(-8)). The observed endometrial cancer odds ratio per rs727479 A-allele (1.15, CI=1.11-1.21) is compatible with that predicted by the observed effect on E2 concentrations (1.09, CI=1.03-1.21), consistent with the hypothesis that endometrial cancer risk is driven by E2. From 28 candidate-causal SNPs, 12 co-located with three putative gene-regulatory elements and their risk alleles associated with higher CYP19A1 expression in bioinformatical analyses. For both phenotypes, the associations with rs727479 were stronger among women with a higher BMI (Pinteraction=0.034 and 0.066 respectively), suggesting a biologically plausible gene-environment interaction.

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ID Code: 91736
Item Type: Journal Article
Refereed: Yes
Additional URLs:
DOI: 10.1530/ERC-15-0386
ISSN: 1479-6821
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2016 The authors
Copyright Statement: This work is licensed under a Creative Commons Attribution 3.0 Unported License
Deposited On: 11 Jan 2016 23:06
Last Modified: 17 Jan 2016 22:00

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