Low birth weight in MZ twins discordant for birth weight is associated with shorter telomere length and lower IQ, but not anxiety/depression in later life

Strohmaier, Jana, van Dongen, Jenny, Willemsen, Gonneke, Nyholt, Dale R., Zhu, Gu, Codd, Veryan, Novakovic, Boris, Hansell, Narelle, Wright, Margaret J., Rietschel, Liz, Streit, Fabian, Henders, Anjali K., Montgomery, Grant W., Samani, Nilesh J., Gillespie, Nathan A., Hickie, Ian B., Craig, Jeffrey M., Saffery, Richard, Boomsma, Dorret I., Rietschel, Marcella, & Martin, Nicholas G. (2015) Low birth weight in MZ twins discordant for birth weight is associated with shorter telomere length and lower IQ, but not anxiety/depression in later life. Twin Research and Human Genetics, 18(2), pp. 198-209.

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Abstract

Shorter telomere length (TL) has found to be associated with lower birth weight and with lower cognitive ability and psychiatric disorders. However, the direction of causation of these associations and the extent to which they are genetically or environmentally mediated are unclear. Within-pair comparisons of monozygotic (MZ) and dizygotic (DZ) twins can throw light on these questions. We investigated correlations of within pair differences in telomere length, IQ, and anxiety/depression in an initial sample from Brisbane (242 MZ pairs, 245 DZ same sex (DZSS) pairs) and in replication samples from Amsterdam (514 MZ pairs, 233 DZSS pairs) and Melbourne (19 pairs selected for extreme high or low birth weight difference). Intra-pair differences of birth weight and telomere length were significantly correlated in MZ twins, but not in DZSS twins. Greater intra-pair differences of telomere length were observed in the 10% of MZ twins with the greatest difference in birth weight compared to the bottom 90% in both samples and also in the Melbourne sample. Intra-pair differences of telomere length and IQ, but not of TL and anxiety/depression, were correlated in MZ twins, and to a smaller extent in DZSS twins. Our findings suggest that the same prenatal effects that reduce birth weight also influence telomere length in MZ twins. The association between telomere length and IQ is partly driven by the same prenatal effects that decrease birth weight.

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ID Code: 91746
Item Type: Journal Article
Refereed: Yes
Keywords: anxiety/depression, birth weight, IQ, telomere length, twins, anxiety, Article, birth weight, depression, disease association, dizygotic twins, female, gene replication, human, intelligence quotient, low birth weight, major clinical study, male, monozygotic twins, newborn, priority journal, telomere homeostasis, twin discordance
DOI: 10.1017/thg.2015.3
ISSN: 1832-4274
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 12 Jan 2016 22:36
Last Modified: 15 Jan 2016 05:13

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