Genome-wide enrichment analysis between endometriosis and obesity-related traits reveals novel susceptibility loci

Rahmioglu, Nilufer, Macgregor, Stuart, Drong, Alexander W., Hedman, Åsa K., Harris, Holly R., Randall, Joshua C., Prokopenko, Inga, Nyholt, Dale R., Morris, Andrew P., Montgomery, Grant W., Missmer, Stacey A., Lindgren, Cecilia M., & Zondervan, Krina T. (2015) Genome-wide enrichment analysis between endometriosis and obesity-related traits reveals novel susceptibility loci. Human Molecular Genetics, 24(4), pp. 1185-1199.

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Endometriosis is a chronic inflammatory condition in women that results in pelvic pain and subfertility, and has been associated with decreased body mass index (BMI). Genetic variants contributing to the heritable component have started to emerge from genome-wide association studies (GWAS), although the majority remain unknown. Unexpectedly, we observed an intergenic locus on 7p15.2 that was genome-wide significantly associated with both endometriosis and fat distribution (waist-to-hip ratio adjusted for BMI; WHRadjBMI) in an independent meta-GWAS of European ancestry individuals. This led us to investigate the potential overlap in genetic variants underlying the aetiology of endometriosis, WHRadjBMI and BMI using GWAS data. Our analyses demonstrated significant enrichment of common variants between fat distribution and endometriosis (P = 3.7 x 10(-3)), which was stronger when we restricted the investigation to more severe (Stage B) cases (P = 4.5 x 10(-4)). However, no genetic enrichment was observed between endometriosis and BMI (P = 0.79). In addition to 7p15.2, we identify four more variants with statistically significant evidence of involvement in both endometriosis and WHRadjBMI (in/near KIFAP3, CAB39L, WNT4, GRB14); two of these, KIFAP3 and CAB39L, are novel associations for both traits. KIFAP3, WNT4 and 7p15.2 are associated with the WNT signalling pathway; formal pathway analysis confirmed a statistically significant (P = 6.41 x 10(-4)) overrepresentation of shared associations in developmental processes/WNT signalling between the two traits. Our results demonstrate an example of potential biological pleiotropy that was hitherto unknown, and represent an opportunity for functional follow-up of loci and further cross-phenotype comparisons to assess how fat distribution and endometriosis pathogenesis research fields can inform each other.

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ID Code: 91777
Item Type: Journal Article
Refereed: Yes
Keywords: Adiposity/genetics, Adult, Alleles, Chromosomes, Human, Pair 7, Endometriosis/diagnosis/*etiology/metabolism, Female, *Genetic Predisposition to Disease, *Genome-Wide Association Study, Humans, Obesity/*complications/*genetics, Odds Ratio, *Quantitative Trait Loci, *Quantitative Trait, Heritable, Signal Transduction
DOI: 10.1093/hmg/ddu516
ISSN: 1460-2083
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 12 Jan 2016 23:38
Last Modified: 13 Jan 2016 21:31

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