No genetic support for a contribution of prostaglandins to the aetiology of androgenetic alopecia

Heilmann, S., Nyholt, D.R., Brockschmidt, F.F., Hillmer, A.M., Herold, C., Becker, T., Martin, N.G., & Nothen, M.M. (2013) No genetic support for a contribution of prostaglandins to the aetiology of androgenetic alopecia. British Journal of Dermatology, 169(1), pp. 222-224.

View at publisher


MADAM, Androgenetic alopecia (AGA) is a common age-dependent trait, characterized by a progressive loss of hair from the scalp. The hair loss may commence during puberty and up to 80% of white men experience some degree of AGA during their lifetime.1 Research has established that two essential aetiological factors for AGA are a genetic predisposition and the presence of androgens (male sex hormones).1,2 A recent meta-analysis of genome-wide association studies (GWAS) has increased the number of identified loci associated with this trait at the molecular level to a total of eight.3 However, despite these successes, a large fraction of the genetic contribution remains to be identified. One way to identify further genetic loci is to combine the resource of GWAS datasets with knowledge about specific biological factors likely to be involved in the development of disease. The focused evaluation of a limited number of candidate genes in GWAS datasets avoids the necessity for extensive correction for multiple testing, which typically limits the power for detecting genetic loci at a genome-wide level.4 Because the presence of genetic association suggests that candidate genes are likely to operate early in the causative chain of events leading to the phenotype, this approach may also function to favour biological pathways for their importance in the development of AGA.

Impact and interest:

1 citations in Scopus
1 citations in Web of Science®
Search Google Scholar™

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 91828
Item Type: Journal Article
Refereed: Yes
Keywords: Alopecia/*genetics, Humans, Prostaglandin D2/*genetics/metabolism, Receptors, Immunologic/*genetics, Receptors, Prostaglandin/*genetics
DOI: 10.1111/bjd.12292
ISSN: 1365-2133
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 14 Jan 2016 04:05
Last Modified: 15 Jan 2016 05:50

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page