Genome-wide meta-analysis identifies new susceptibility loci for migraine

Anttila, V., Winsvold, B. S., Gormley, P., Kurth, T., Bettella, F., McMahon, G., Kallela, M., Malik, R., de Vries, B., Terwindt, G., Medland, S. E., Todt, U., McArdle, W. L., Quaye, L., Koiranen, M., Ikram, M. A., Lehtimaki, T., Stam, A. H., Ligthart, L., Wedenoja, J., Dunham, I., Neale, B. M., Palta, P., Hamalainen, E., Schurks, M., Rose, L. M., Buring, J. E., Ridker, P. M., Steinberg, S., Stefansson, H., Jakobsson, F., Lawlor, D. A., Evans, D. M., Ring, S. M., Farkkila, M., Artto, V., Kaunisto, M. A., Freilinger, T., Schoenen, J., Frants, R. R., Pelzer, N., Weller, C. M., Zielman, R., Heath, A. C., Madden, P. A., Montgomery, G. W., Martin, N. G., Borck, G., Gobel, H., Heinze, A., Heinze-Kuhn, K., Williams, F. M., Hartikainen, A. L., Pouta, A., van den Ende, J., Uitterlinden, A. G., Hofman, A., Amin, N., Hottenga, J. J., Vink, J. M., Heikkila, K., Alexander, M., Muller-Myhsok, B., Schreiber, S., Meitinger, T., Wichmann, H. E., Aromaa, A., Eriksson, J. G., Traynor, B. J., Trabzuni, D., Rossin, E., Lage, K., Jacobs, S. B., Gibbs, J. R., Birney, E., Kaprio, J., Penninx, B. W., Boomsma, D. I., van Duijn, C., Raitakari, O., Jarvelin, M. R., Zwart, J. A., Cherkas, L., Strachan, D. P., Kubisch, C., Ferrari, M. D., van den Maagdenberg, A. M., Dichgans, M., Wessman, M., Smith, G. D., Stefansson, K., Daly, M. J., Nyholt, D.R., Chasman, D. I., & Palotie, A. (2013) Genome-wide meta-analysis identifies new susceptibility loci for migraine. Nature Genetics, 45(8), pp. 912-917.

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Abstract

Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P<5x10(-8)). Five loci are new: near AJAP1 at 1p36, near TSPAN2 at 1p13, within FHL5 at 6q16, within C7orf10 at 7p14 and near MMP16 at 8q21. Three of these loci were identified in disease subgroup analyses. Brain tissue expression quantitative trait locus analysis suggests potential functional candidate genes at four loci: APOA1BP, TBC1D7, FUT9, STAT6 and ATP5B.

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ID Code: 91835
Item Type: Journal Article
Refereed: Yes
Keywords: Cerebellum/metabolism, Computational Biology, Frontal Lobe/metabolism, *Genetic Loci, *Genetic Predisposition to Disease, *Genome-Wide Association Study, Humans, Migraine Disorders/*genetics, Polymorphism, Single Nucleotide, Quantitative Trait Loci
DOI: 10.1038/ng.2676
ISSN: 1546-1718
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 14 Jan 2016 03:24
Last Modified: 15 Jan 2016 05:25

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