Genome-wide meta-analysis of common variant differences between men and women

Boraska, V., Jeroncic, A., Colonna, V., Southam, L., Nyholt, D.R., Rayner, N.W., Perry, J.R., Toniolo, D., Albrecht, E., Ang, W., Bandinelli, S., Barbalic, M., Barroso, I., Beckmann, J.S., Biffar, R., Boomsma, D., Campbell, H., Corre, T., Erdmann, J., Esko, T., Fischer, K., Franceschini, N., Frayling, T.M., Girotto, G., Gonzalez, J.R., Harris, T.B., Heath, A.C., Heid, I.M., Hoffmann, W., Hofman, A., Horikoshi, M., Zhao, J.H., Jackson, A.U., Hottenga, J.J., Jula, A., Kahonen, M., Khaw, K.T., Kiemeney, L.A., Klopp, N., Kutalik, Z., Lagou, V., Launer, L.J., Lehtimaki, T., Lemire, M., Lokki, M.L., Loley, C., Luan, J., Mangino, M., Mateo Leach, I., Medland, S.E., Mihailov, E., Montgomery, G.W., Navis, G., Newnham, J., Nieminen, M.S., Palotie, A., Panoutsopoulou, K., Peters, A., Pirastu, N., Polasek, O., Rehnstrom, K., Ripatti, S., Ritchie, G.R., Rivadeneira, F., Robino, A., Samani, N.J., Shin, S.Y., Sinisalo, J., Smit, J.H., Soranzo, N., Stolk, L., Swinkels, D.W., Tanaka, T., Teumer, A., Tonjes, A., Traglia, M., Tuomilehto, J., Valsesia, A., van Gilst, W.H., van Meurs, J.B., Smith, A.V., Viikari, J., Vink, J.M., Waeber, G., Warrington, N.M., Widen, E., Willemsen, G., Wright, A.F., Zanke, B.W., Zgaga, L., Boehnke, M., d'Adamo, A.P., de Geus, E., Demerath, W., den Heijer, M., Eriksson, J.G., Ferrucci, L., Gieger, C., Gudnason, V., Hayward, C., Hengstenberg, C., Hudson, T.J., Jarvelin, M.R., Kogevinas, M., Loos, R.J., Martin, N.G., Metspalu, A., Pennell, C.E., Penninx, B.W., Perola, M., Raitakari, O., Salomaa, V., Schreiber, S., Schunkert, H., Spector, T.D., Stumvoll, M., Uitterlinden, A.G., Ulivi, S., van der Harst, P., Vollenweider, P., Volzke, H., Wareham, N.J., Wichmann, H.E., Wilson, J.F., Rudan, I., Xue, Y., & Zeggini, E. (2012) Genome-wide meta-analysis of common variant differences between men and women. Human Molecular Genetics, 21(21), pp. 4805-4815.

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The male-to-female sex ratio at birth is constant across world populations with an average of 1.06 (106 male to 100 female live births) for populations of European descent. The sex ratio is considered to be affected by numerous biological and environmental factors and to have a heritable component. The aim of this study was to investigate the presence of common allele modest effects at autosomal and chromosome X variants that could explain the observed sex ratio at birth. We conducted a large-scale genome-wide association scan (GWAS) meta-analysis across 51 studies, comprising overall 114 863 individuals (61 094 women and 53 769 men) of European ancestry and 2 623 828 common (minor allele frequency >0.05) single-nucleotide polymorphisms (SNPs). Allele frequencies were compared between men and women for directly-typed and imputed variants within each study. Forward-time simulations for unlinked, neutral, autosomal, common loci were performed under the demographic model for European populations with a fixed sex ratio and a random mating scheme to assess the probability of detecting significant allele frequency differences. We do not detect any genome-wide significant (P < 5 x 10(-8)) common SNP differences between men and women in this well-powered meta-analysis. The simulated data provided results entirely consistent with these findings. This large-scale investigation across ~115 000 individuals shows no detectable contribution from common genetic variants to the observed skew in the sex ratio. The absence of sex-specific differences is useful in guiding genetic association study design, for example when using mixed controls for sex-biased traits.

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ID Code: 91850
Item Type: Journal Article
Refereed: Yes
Keywords: European Continental Ancestry Group/genetics, Female, Gene Frequency, *Genome-Wide Association Study, Humans, Male, *Models, Genetic, *Polymorphism, Single Nucleotide, *Sex Factors, Sex Ratio, Sexism
DOI: 10.1093/hmg/dds304
ISSN: 1460-2083
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 13 Jan 2016 03:11
Last Modified: 14 Jan 2016 02:28

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