No influence of 5-HTTLPR gene polymorphism on migraine symptomatology, comorbid depression, and chronification

Wieser, T., Dresler, K., Evers, S., Gaul, C., Konig, D., Holzl, D., Berger, K., Nyholt, D.R., & Deufel, T. (2010) No influence of 5-HTTLPR gene polymorphism on migraine symptomatology, comorbid depression, and chronification. Headache, 50(3), pp. 420-430.

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The serotonergic system is thought to play an important role for mediating susceptibility to migraine and depression, which is frequently found comorbid in migraine. The functional polymorphism in the serotonin transporter gene linked polymorphic region (5-HTTLPR/SLC6A4) was previously associated with attack frequency and, thus, possibly with chronification.


We hypothesized that patients with the "s" allele have higher attack frequency and, paralleling results in depression research, higher scores of depression. METHODS: Genetic analysis of the SLC6A4 44 bp insertion/deletion polymorphism (5-HTTLPR) was performed in 293 patients with migraine with and without aura. Self-rating questionnaires were used for assessment of depression.


Multinomial logistic regression analysis found no evidence for association of the 5-HTTLPR polymorphism with either depression or migraine attack frequency.


We were not able to demonstrate any influence of the serotonin transporter 5-HTTLPR polymorphism on migraine phenomenology (attack frequency or comorbid depression), thereby excluding this variant to be a common genetic denominator for chronic migraine and depression.

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11 citations in Web of Science®
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ID Code: 91972
Item Type: Journal Article
Refereed: Yes
Additional Information: Wieser, Thomas
Dresler, Kathrin
Evers, Stefan
Gaul, Charly
Konig, Dorothea
Holzl, Daniela
Berger, Klaus
Nyholt, Dale
Deufel, Thomas
2009/05/15 09:00
Headache. 2010 Mar;50(3):420-30. doi: 10.1111/j.1526-4610.2009.01428.x. Epub 2009 Apr 27.
Keywords: Adult, Brain Chemistry/genetics, Cohort Studies, Comorbidity, Cross-Sectional Studies, DNA Mutational Analysis, Depressive Disorder/epidemiology/*genetics/physiopathology, Female, Gene Frequency/genetics, Genetic Markers/genetics, Genetic Predisposition to Disease/*genetics, Genetic Testing, Humans, Male, Middle Aged, Migraine Disorders/epidemiology/*genetics/physiopathology, Polymorphism, Genetic/*genetics, Questionnaires, Regression Analysis, Serotonin/metabolism, Serotonin Plasma Membrane Transport Proteins/*genetics, Time Factors
DOI: 10.1111/j.1526-4610.2009.01428.x
ISSN: 0017-8748
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 18 Jan 2016 00:29
Last Modified: 15 Feb 2016 00:25

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