A genome-wide association study of Cloninger's temperament scales: implications for the evolutionary genetics of personality

Verweij, K. J., Zietsch, B. P., Medland, S. E., Gordon, S. D., Benyamin, B., Nyholt, D.R., McEvoy, B. P., Sullivan, P. F., Heath, A. C., Madden, P. A., Henders, A. K., Montgomery, G. W., Martin, N. G., & Wray, N. R. (2010) A genome-wide association study of Cloninger's temperament scales: implications for the evolutionary genetics of personality. Biological Psychology, 85(2), pp. 306-317.

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Variation in personality traits is 30-60% attributed to genetic influences. Attempts to unravel these genetic influences at the molecular level have, so far, been inconclusive. We performed the first genome-wide association study of Cloninger's temperament scales in a sample of 5117 individuals, in order to identify common genetic variants underlying variation in personality. Participants' scores on Harm Avoidance, Novelty Seeking, Reward Dependence, and Persistence were tested for association with 1,252,387 genetic markers. We also performed gene-based association tests and biological pathway analyses. No genetic variants that significantly contribute to personality variation were identified, while our sample provides over 90% power to detect variants that explain only 1% of the trait variance. This indicates that individual common genetic variants of this size or greater do not contribute to personality trait variation, which has important implications regarding the genetic architecture of personality and the evolutionary mechanisms by which heritable variation is maintained.

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ID Code: 91973
Item Type: Journal Article
Refereed: Yes
Additional Information: Verweij, Karin J H Zietsch, Brendan P Medland, Sarah E Gordon, Scott D Benyamin, Beben Nyholt, Dale R McEvoy, Brian P Sullivan, Patrick F Heath, Andrew C Madden, Pamela A F Henders, Anjali K Montgomery, Grant W Martin, Nicholas G Wray, Naomi R eng AA07535/AA/NIAAA NIH HHS/ AA10248/AA/NIAAA NIH HHS/ AA13320/AA/NIAAA NIH HHS/ AA13321/AA/NIAAA NIH HHS/ AA13326/AA/NIAAA NIH HHS/ AA14041/AA/NIAAA NIH HHS/ K05 AA017688/AA/NIAAA NIH HHS/ MH66206/MH/NIMH NIH HHS/ R01 AA007535/AA/NIAAA NIH HHS/ R01 AA013321/AA/NIAAA NIH HHS/ R01 DA012854/DA/NIDA NIH HHS/ R01 MH066206/MH/NIMH NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Twin Study Netherlands 2010/08/10 06:00 Biol Psychol. 2010 Oct;85(2):306-17. doi: 10.1016/j.biopsycho.2010.07.018. Epub 2010 Aug 4.
Keywords: Adult, Age Factors, Exploratory Behavior, Female, Genome-Wide Association Study, Genotype, Humans, Life Style, Male, Middle Aged, Personality/*genetics, Questionnaires, Reward, Temperament, Twins/*genetics
DOI: 10.1016/j.biopsycho.2010.07.018
ISSN: 0301-0511
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: © 2010 Elsevier B.V
Deposited On: 18 Jan 2016 00:40
Last Modified: 15 Feb 2016 00:58

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